Preliminary Efficacy of Growth Hormone Therapy in Children With Congenital HeartDisease and Short Stature: A Six-case Report and Literature Review
Congenital heart disease (CHD) is a congenital malformation resulting from abnormal embryonic development of the heart and great vessels, accounting for approximately 25% of all congenital malformations. Children with CHD are often complicated by short stature. Although surgical treatment can improv...
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2025-05-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2025-0147 |
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| author | YANG Xi LIANG Siyu LI Qianqian DU Hanze SONG Shuaihua JIANG Yue MA Huijuan CHEN Shi PAN Hui |
| author_facet | YANG Xi LIANG Siyu LI Qianqian DU Hanze SONG Shuaihua JIANG Yue MA Huijuan CHEN Shi PAN Hui |
| author_sort | YANG Xi |
| collection | DOAJ |
| description | Congenital heart disease (CHD) is a congenital malformation resulting from abnormal embryonic development of the heart and great vessels, accounting for approximately 25% of all congenital malformations. Children with CHD are often complicated by short stature. Although surgical treatment can improve their growth and development to a certain extent, some children still experience growth retardation after surgery. Recombinant human growth hormone (rhGH) is the main drug for treating short stature, but its efficacy and safety in the treatment of patients with concomitant CHD warrant further investigation. This article reports six cases of children with CHD and short stature who were treated with rhGH. Through a literature review, we summarize and discuss the therapeutic efficacy, follow-up experiences, and adverse reactions of rhGH treatment, aiming to provide references for clinicians in applying rhGH to treat patients with CHD and short stature. |
| format | Article |
| id | doaj-art-7e98ce9df85f4d6b930d4b2c3c845d5f |
| institution | OA Journals |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2025-05-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-7e98ce9df85f4d6b930d4b2c3c845d5f2025-08-20T02:03:24ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812025-05-0116364164610.12290/xhyxzz.2025-0147Preliminary Efficacy of Growth Hormone Therapy in Children With Congenital HeartDisease and Short Stature: A Six-case Report and Literature ReviewYANG XiLIANG Siyu0LI Qianqian1DU Hanze2SONG Shuaihua3JIANG Yue4MA Huijuan5CHEN Shi6PAN Hui7Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Endocrinology, Genetics and Metabolism, Hebei Children's Hospital, Shijiazhuang 050031, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Endocrinology, The First Hospital of Hebei Medical University, Shijiazhuang 050031, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaCongenital heart disease (CHD) is a congenital malformation resulting from abnormal embryonic development of the heart and great vessels, accounting for approximately 25% of all congenital malformations. Children with CHD are often complicated by short stature. Although surgical treatment can improve their growth and development to a certain extent, some children still experience growth retardation after surgery. Recombinant human growth hormone (rhGH) is the main drug for treating short stature, but its efficacy and safety in the treatment of patients with concomitant CHD warrant further investigation. This article reports six cases of children with CHD and short stature who were treated with rhGH. Through a literature review, we summarize and discuss the therapeutic efficacy, follow-up experiences, and adverse reactions of rhGH treatment, aiming to provide references for clinicians in applying rhGH to treat patients with CHD and short stature.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2025-0147congenital heart diseaseshort staturerecombinant human growth hormonegrowth retardationcongenital malformation |
| spellingShingle | YANG Xi LIANG Siyu LI Qianqian DU Hanze SONG Shuaihua JIANG Yue MA Huijuan CHEN Shi PAN Hui Preliminary Efficacy of Growth Hormone Therapy in Children With Congenital HeartDisease and Short Stature: A Six-case Report and Literature Review Xiehe Yixue Zazhi congenital heart disease short stature recombinant human growth hormone growth retardation congenital malformation |
| title | Preliminary Efficacy of Growth Hormone Therapy in Children With Congenital HeartDisease and Short Stature: A Six-case Report and Literature Review |
| title_full | Preliminary Efficacy of Growth Hormone Therapy in Children With Congenital HeartDisease and Short Stature: A Six-case Report and Literature Review |
| title_fullStr | Preliminary Efficacy of Growth Hormone Therapy in Children With Congenital HeartDisease and Short Stature: A Six-case Report and Literature Review |
| title_full_unstemmed | Preliminary Efficacy of Growth Hormone Therapy in Children With Congenital HeartDisease and Short Stature: A Six-case Report and Literature Review |
| title_short | Preliminary Efficacy of Growth Hormone Therapy in Children With Congenital HeartDisease and Short Stature: A Six-case Report and Literature Review |
| title_sort | preliminary efficacy of growth hormone therapy in children with congenital heartdisease and short stature a six case report and literature review |
| topic | congenital heart disease short stature recombinant human growth hormone growth retardation congenital malformation |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2025-0147 |
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