A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming

A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming

Abstract Cancer‐associated fibroblasts (CAFs) are key regulators of tumorigenesis and promising targets for next‐generation therapies. We discovered that cancer cell‐derived activin A reprograms fibroblasts into pro‐tumorigenic CAFs. Mechanistically, this occurs via Smad2‐mediated transcriptional re...

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Bibliographic Details
Main Authors: Michael Cangkrama, Mateusz Wietecha, Nicolas Mathis, Rin Okumura, Luca Ferrarese, Dunja Al‐Nuaimi, Maria Antsiferova, Reinhard Dummer, Metello Innocenti, Sabine Werner
Format: Article
Language:English
Published: Springer Nature 2020-03-01
Series:EMBO Molecular Medicine
Subjects:
activin
CAF
carcinogenesis
mDia2
tumor microenvironment
Online Access:https://doi.org/10.15252/emmm.201911466
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