Modeling the Effects of Protracted Cosmic Radiation in a Human Organ‐on‐Chip Platform
Abstract Galactic cosmic radiation (GCR) is one of the most serious risks posed to astronauts during missions to the Moon and Mars. Experimental models capable of recapitulating human physiology are critical to understanding the effects of radiation on human organs and developing radioprotective mea...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202401415 |
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| author | Daniel Naveed Tavakol Trevor R. Nash Youngbin Kim Pamela L. Graney Martin Liberman Sharon Fleischer Roberta I. Lock Aaron O'Donnell Leah Andrews Derek Ning Keith Yeager Andrew Harken Naresh Deoli Sally A. Amundson Guy Garty Kam W. Leong David J. Brenner Gordana Vunjak‐Novakovic |
| author_facet | Daniel Naveed Tavakol Trevor R. Nash Youngbin Kim Pamela L. Graney Martin Liberman Sharon Fleischer Roberta I. Lock Aaron O'Donnell Leah Andrews Derek Ning Keith Yeager Andrew Harken Naresh Deoli Sally A. Amundson Guy Garty Kam W. Leong David J. Brenner Gordana Vunjak‐Novakovic |
| author_sort | Daniel Naveed Tavakol |
| collection | DOAJ |
| description | Abstract Galactic cosmic radiation (GCR) is one of the most serious risks posed to astronauts during missions to the Moon and Mars. Experimental models capable of recapitulating human physiology are critical to understanding the effects of radiation on human organs and developing radioprotective measures against space travel exposures. The effects of systemic radiation are studied using a multi‐organ‐on‐a‐chip (multi‐OoC) platform containing engineered tissue models of human bone marrow (site of hematopoiesis and acute radiation damage), cardiac muscle (site of chronic radiation damage) and liver (site of metabolism), linked by vascular circulation with an endothelial barrier separating individual tissue chambers from the vascular perfusate. Following protracted neutron radiation, the most damaging radiation component in deep space, a greater deviation of tissue function is observed as compared to the same cumulative dose delivered acutely. Further, by characterizing engineered bone marrow (eBM)‐derived immune cells in circulation, 58 unique genes specific to the effects of protracted neutron dosing are identified, as compared to acutely irradiated and healthy tissues. It propose that this bioengineered platform allows studies of human responses to extended radiation exposure in an “astronaut‐on‐a‐chip” model that can inform measures for mitigating cosmic radiation injury. |
| format | Article |
| id | doaj-art-7e92c8cf27d14e3786d3ad5685ed5b4e |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-7e92c8cf27d14e3786d3ad5685ed5b4e2025-08-20T02:15:33ZengWileyAdvanced Science2198-38442024-11-011142n/an/a10.1002/advs.202401415Modeling the Effects of Protracted Cosmic Radiation in a Human Organ‐on‐Chip PlatformDaniel Naveed Tavakol0Trevor R. Nash1Youngbin Kim2Pamela L. Graney3Martin Liberman4Sharon Fleischer5Roberta I. Lock6Aaron O'Donnell7Leah Andrews8Derek Ning9Keith Yeager10Andrew Harken11Naresh Deoli12Sally A. Amundson13Guy Garty14Kam W. Leong15David J. Brenner16Gordana Vunjak‐Novakovic17Department of Biomedical Engineering Columbia University New York NY 10032 USADepartment of Biomedical Engineering Columbia University New York NY 10032 USADepartment of Biomedical Engineering Columbia University New York NY 10032 USADepartment of Biomedical Engineering Columbia University New York NY 10032 USADepartment of Biomedical Engineering Columbia University New York NY 10032 USADepartment of Biomedical Engineering Columbia University New York NY 10032 USADepartment of Biomedical Engineering Columbia University New York NY 10032 USADepartment of Biomedical Engineering Columbia University New York NY 10032 USADepartment of Biomedical Engineering Columbia University New York NY 10032 USADepartment of Biomedical Engineering Columbia University New York NY 10032 USADepartment of Biomedical Engineering Columbia University New York NY 10032 USACenter for Radiological Research Columbia University New York NY 10032 USACenter for Radiological Research Columbia University New York NY 10032 USACenter for Radiological Research Columbia University New York NY 10032 USACenter for Radiological Research Columbia University New York NY 10032 USADepartment of Biomedical Engineering Columbia University New York NY 10032 USACenter for Radiological Research Columbia University New York NY 10032 USADepartment of Biomedical Engineering Department of Medicine, and College of Dental Medicine Columbia University New York NY 10032 USAAbstract Galactic cosmic radiation (GCR) is one of the most serious risks posed to astronauts during missions to the Moon and Mars. Experimental models capable of recapitulating human physiology are critical to understanding the effects of radiation on human organs and developing radioprotective measures against space travel exposures. The effects of systemic radiation are studied using a multi‐organ‐on‐a‐chip (multi‐OoC) platform containing engineered tissue models of human bone marrow (site of hematopoiesis and acute radiation damage), cardiac muscle (site of chronic radiation damage) and liver (site of metabolism), linked by vascular circulation with an endothelial barrier separating individual tissue chambers from the vascular perfusate. Following protracted neutron radiation, the most damaging radiation component in deep space, a greater deviation of tissue function is observed as compared to the same cumulative dose delivered acutely. Further, by characterizing engineered bone marrow (eBM)‐derived immune cells in circulation, 58 unique genes specific to the effects of protracted neutron dosing are identified, as compared to acutely irradiated and healthy tissues. It propose that this bioengineered platform allows studies of human responses to extended radiation exposure in an “astronaut‐on‐a‐chip” model that can inform measures for mitigating cosmic radiation injury.https://doi.org/10.1002/advs.202401415bone marrowhearthuman stem cellslivermars missionorgan‐on‐chip |
| spellingShingle | Daniel Naveed Tavakol Trevor R. Nash Youngbin Kim Pamela L. Graney Martin Liberman Sharon Fleischer Roberta I. Lock Aaron O'Donnell Leah Andrews Derek Ning Keith Yeager Andrew Harken Naresh Deoli Sally A. Amundson Guy Garty Kam W. Leong David J. Brenner Gordana Vunjak‐Novakovic Modeling the Effects of Protracted Cosmic Radiation in a Human Organ‐on‐Chip Platform Advanced Science bone marrow heart human stem cells liver mars mission organ‐on‐chip |
| title | Modeling the Effects of Protracted Cosmic Radiation in a Human Organ‐on‐Chip Platform |
| title_full | Modeling the Effects of Protracted Cosmic Radiation in a Human Organ‐on‐Chip Platform |
| title_fullStr | Modeling the Effects of Protracted Cosmic Radiation in a Human Organ‐on‐Chip Platform |
| title_full_unstemmed | Modeling the Effects of Protracted Cosmic Radiation in a Human Organ‐on‐Chip Platform |
| title_short | Modeling the Effects of Protracted Cosmic Radiation in a Human Organ‐on‐Chip Platform |
| title_sort | modeling the effects of protracted cosmic radiation in a human organ on chip platform |
| topic | bone marrow heart human stem cells liver mars mission organ‐on‐chip |
| url | https://doi.org/10.1002/advs.202401415 |
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