Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens.

Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens.

A number of pathogens, including several human-restricted organisms, persist and replicate within macrophages (Mφs) as a key step in pathogenesis. The mechanisms underpinning such host-restricted intracellular adaptations are poorly understood, in part, due to a lack of appropriate model systems. He...

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Bibliographic Details
Main Authors: Christine Hale, Amy Yeung, David Goulding, Derek Pickard, Kaur Alasoo, Fiona Powrie, Gordon Dougan, Subhankar Mukhopadhyay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0124307
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