Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases
Mitochondria and lysosomes are critical for neuronal homeostasis, as highlighted by their dysfunction in various neurological diseases. Recent studies have identified dynamic membrane contact sites between mitochondria and lysosomes, independent of mitophagy and the lysosomal degradation of mitochon...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2024.1527013/full |
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| author | Yinyin Xie Wenlin Sun Aoya Han Xinru Zhou Shijie Zhang Changchang Shen Yi Xie Cui Wang Nanchang Xie |
| author_facet | Yinyin Xie Wenlin Sun Aoya Han Xinru Zhou Shijie Zhang Changchang Shen Yi Xie Cui Wang Nanchang Xie |
| author_sort | Yinyin Xie |
| collection | DOAJ |
| description | Mitochondria and lysosomes are critical for neuronal homeostasis, as highlighted by their dysfunction in various neurological diseases. Recent studies have identified dynamic membrane contact sites between mitochondria and lysosomes, independent of mitophagy and the lysosomal degradation of mitochondrial-derived vesicles (MDVs), allowing bidirectional crosstalk between these cell compartments, the dynamic regulation of organelle networks, and substance exchanges. Emerging evidence suggests that abnormalities in mitochondria-lysosome contact sites (MLCSs) contribute to neurological diseases, including Parkinson’s disease, Charcot–Marie-Tooth (CMT) disease, lysosomal storage diseases, and epilepsy. This article reviews recent research advances regarding the tethering processes, regulation, and function of MLCSs and their role in neurological diseases. |
| format | Article |
| id | doaj-art-7e8ee871e74d4e22b213970cbc377df1 |
| institution | Kabale University |
| issn | 1662-5099 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj-art-7e8ee871e74d4e22b213970cbc377df12025-01-14T06:10:40ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992025-01-011710.3389/fnmol.2024.15270131527013Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseasesYinyin Xie0Wenlin Sun1Aoya Han2Xinru Zhou3Shijie Zhang4Changchang Shen5Yi Xie6Cui Wang7Nanchang Xie8Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Key Clinical Laboratory of Henan Province, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaMitochondria and lysosomes are critical for neuronal homeostasis, as highlighted by their dysfunction in various neurological diseases. Recent studies have identified dynamic membrane contact sites between mitochondria and lysosomes, independent of mitophagy and the lysosomal degradation of mitochondrial-derived vesicles (MDVs), allowing bidirectional crosstalk between these cell compartments, the dynamic regulation of organelle networks, and substance exchanges. Emerging evidence suggests that abnormalities in mitochondria-lysosome contact sites (MLCSs) contribute to neurological diseases, including Parkinson’s disease, Charcot–Marie-Tooth (CMT) disease, lysosomal storage diseases, and epilepsy. This article reviews recent research advances regarding the tethering processes, regulation, and function of MLCSs and their role in neurological diseases.https://www.frontiersin.org/articles/10.3389/fnmol.2024.1527013/fulllysosomal dynamicsmitochondria-lysosome contact sitesmitochondrial networkmitophagyneurological diseasessubstance exchanges |
| spellingShingle | Yinyin Xie Wenlin Sun Aoya Han Xinru Zhou Shijie Zhang Changchang Shen Yi Xie Cui Wang Nanchang Xie Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases Frontiers in Molecular Neuroscience lysosomal dynamics mitochondria-lysosome contact sites mitochondrial network mitophagy neurological diseases substance exchanges |
| title | Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases |
| title_full | Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases |
| title_fullStr | Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases |
| title_full_unstemmed | Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases |
| title_short | Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases |
| title_sort | novel strategies targeting mitochondria lysosome contact sites for the treatment of neurological diseases |
| topic | lysosomal dynamics mitochondria-lysosome contact sites mitochondrial network mitophagy neurological diseases substance exchanges |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2024.1527013/full |
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