Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives
Three series of isatin derivatives [3-hydrazino, 3-thiosemicarbazino, and 3-imino carboxylic acid derivatives] were synthesized employing microwave irradiation. The prepared compounds were characterized by FT-IR, NMR, elemental analysis, and X-ray crystallography for derivatives 5b. The synthesized...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/716987 |
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| author | Ayman El-Faham Wael N. Hozzein Mohammad A. M. Wadaan Sherine N. Khattab Hazem A. Ghabbour Hoong-Kun Fun Mohammed Rafiq Siddiqui |
| author_facet | Ayman El-Faham Wael N. Hozzein Mohammad A. M. Wadaan Sherine N. Khattab Hazem A. Ghabbour Hoong-Kun Fun Mohammed Rafiq Siddiqui |
| author_sort | Ayman El-Faham |
| collection | DOAJ |
| description | Three series of isatin derivatives [3-hydrazino, 3-thiosemicarbazino, and 3-imino carboxylic acid derivatives] were synthesized employing microwave irradiation. The prepared compounds were characterized by FT-IR, NMR, elemental analysis, and X-ray crystallography for derivatives 5b. The synthesized compounds were screened for antimicrobial activity against selected bacteria and fungi. The results revealed that the N-alkyl isatin derivatives were biologically active with different spectrums activity. Most of the 3-hydrazino and 3-thiosemicarbazino isatin derivatives were biologically inactive and generally the active derivatives showed weak to moderate activity mainly against Gram-positive bacteria. The imino isatin carboxylic acid derivatives (2-[4-(1-benzyl-5-bromo-2-oxoindolin-3-ylideneamino) phenyl]acetic acid, 5d) showed promising activity against all tested Gram-positive bacteria and against fungal pathogens. |
| format | Article |
| id | doaj-art-7e8b3046884b4b37b9e642b495244be6 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-7e8b3046884b4b37b9e642b495244be62025-02-03T01:32:17ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/716987716987Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin DerivativesAyman El-Faham0Wael N. Hozzein1Mohammad A. M. Wadaan2Sherine N. Khattab3Hazem A. Ghabbour4Hoong-Kun Fun5Mohammed Rafiq Siddiqui6Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaBioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaBioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, EgyptDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaThree series of isatin derivatives [3-hydrazino, 3-thiosemicarbazino, and 3-imino carboxylic acid derivatives] were synthesized employing microwave irradiation. The prepared compounds were characterized by FT-IR, NMR, elemental analysis, and X-ray crystallography for derivatives 5b. The synthesized compounds were screened for antimicrobial activity against selected bacteria and fungi. The results revealed that the N-alkyl isatin derivatives were biologically active with different spectrums activity. Most of the 3-hydrazino and 3-thiosemicarbazino isatin derivatives were biologically inactive and generally the active derivatives showed weak to moderate activity mainly against Gram-positive bacteria. The imino isatin carboxylic acid derivatives (2-[4-(1-benzyl-5-bromo-2-oxoindolin-3-ylideneamino) phenyl]acetic acid, 5d) showed promising activity against all tested Gram-positive bacteria and against fungal pathogens.http://dx.doi.org/10.1155/2015/716987 |
| spellingShingle | Ayman El-Faham Wael N. Hozzein Mohammad A. M. Wadaan Sherine N. Khattab Hazem A. Ghabbour Hoong-Kun Fun Mohammed Rafiq Siddiqui Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives Journal of Chemistry |
| title | Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives |
| title_full | Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives |
| title_fullStr | Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives |
| title_full_unstemmed | Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives |
| title_short | Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives |
| title_sort | microwave synthesis characterization and antimicrobial activity of some novel isatin derivatives |
| url | http://dx.doi.org/10.1155/2015/716987 |
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