Diagnostic Utility of Gene Expert MTB / RIF in Extra pulmonary koch's
Introduction: Extra Pulmonary TB represents 15% of total TB cases. EPTB is paucibacillary and its diagnosis still remains problematic and emergence of resistant strains poses a significant threat. This study assess the diagnostic accuracy of Gene Xpert MTB in EPTB. Methods: 164 extra pulmonary sampl...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224006271 |
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| Summary: | Introduction: Extra Pulmonary TB represents 15% of total TB cases. EPTB is paucibacillary and its diagnosis still remains problematic and emergence of resistant strains poses a significant threat. This study assess the diagnostic accuracy of Gene Xpert MTB in EPTB. Methods: 164 extra pulmonary samples from clinically suspected tuberculosis were included in this study. Samples included were fluid (Pleural,CSF Synovial and ascitic fluid), Biopsy (Pleura, Bone, Synovium and Lymph node). Lymph node aspirate, Pus and Urine. Samples were taken as per standard protocol. Out of 164 samples 66 were fluids, 42 biopsy, 30 lymph node aspirates, 20 pus and 6 were urine samples. All specimens were processed for Gene Xpert assay. Results: Out of 164 samples, Gene Expert for MTB were positive in 72 samples and Rifampicin resistance was detected in 4 samples. Among these Biopsy specimens showed maximum positivity {31 out of 42). Others: Fluids (8 out of 66), Lymph node aspirate (19 out of 30) Pus (13 out of 20) and Urine (1 out 6) Conclusion: Gene Xpert MTB/RIF assay is simple reliable rapid and highly sensitive method for diagnosing Extra Pulmonary TB and should be given top priority to save time and facilitate a definitive diagnosis and initiate early treatment. Also detection of rifampicin resistance with fairly high sensitivity along short turnout time |
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| ISSN: | 1201-9712 |