Expansion of CD8+CD57+ T Cells in an Immunocompetent Patient with Acute Toxoplasmosis

CD57+ T cells increase in several viral infections like cytomegalovirus, herpesvirus, parvovirus, HIV and hepatitis C virus and are associated with several clinical conditions related to immune dysfunction and ageing. We report for the first time an expansion of CD8+CD57+ T cells in a young patient...

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Main Authors: R. García-Muñoz, P. Rodríguez-Otero, A. Galar, J. Merino, J. J. Beunza, J. A. Páramo, R. Lecumberri
Format: Article
Language:English
Published: Wiley 2009-01-01
Series:Advances in Hematology
Online Access:http://dx.doi.org/10.1155/2009/173439
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author R. García-Muñoz
P. Rodríguez-Otero
A. Galar
J. Merino
J. J. Beunza
J. A. Páramo
R. Lecumberri
author_facet R. García-Muñoz
P. Rodríguez-Otero
A. Galar
J. Merino
J. J. Beunza
J. A. Páramo
R. Lecumberri
author_sort R. García-Muñoz
collection DOAJ
description CD57+ T cells increase in several viral infections like cytomegalovirus, herpesvirus, parvovirus, HIV and hepatitis C virus and are associated with several clinical conditions related to immune dysfunction and ageing. We report for the first time an expansion of CD8+CD57+ T cells in a young patient with an acute infection with Toxoplasma gondii. Our report supports the concept that CD8+CD57+ T cells could be important in the control of chronic phase of intracellular microorganisms and that the high numbers of these cells may reflect the continuing survey of the immune system, searching for parasite proliferation in the tissues.
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institution Kabale University
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series Advances in Hematology
spelling doaj-art-7e85a0ffbe4544fbaea88fc72ee529db2025-08-20T03:35:36ZengWileyAdvances in Hematology1687-91041687-91122009-01-01200910.1155/2009/173439173439Expansion of CD8+CD57+ T Cells in an Immunocompetent Patient with Acute ToxoplasmosisR. García-Muñoz0P. Rodríguez-Otero1A. Galar2J. Merino3J. J. Beunza4J. A. Páramo5R. Lecumberri6Department of Hematology, Hospital San Pedro, Logroño, La Rioja 26006, SpainDepartment of Hematology, University Clinic, University of Navarra, 31008 Navarra, SpainDepartment of Microbiology, University Clinic, University of Navarra, 31008 Navarra, SpainDepartment of Immunology, University Clinic, University of Navarra, 31008 Navarra, SpainDepartment of Preventive Medicine and Public Health, University of Navarra, 31008 Navarra, SpainDepartment of Hematology, University Clinic, University of Navarra, 31008 Navarra, SpainDepartment of Hematology, University Clinic, University of Navarra, 31008 Navarra, SpainCD57+ T cells increase in several viral infections like cytomegalovirus, herpesvirus, parvovirus, HIV and hepatitis C virus and are associated with several clinical conditions related to immune dysfunction and ageing. We report for the first time an expansion of CD8+CD57+ T cells in a young patient with an acute infection with Toxoplasma gondii. Our report supports the concept that CD8+CD57+ T cells could be important in the control of chronic phase of intracellular microorganisms and that the high numbers of these cells may reflect the continuing survey of the immune system, searching for parasite proliferation in the tissues.http://dx.doi.org/10.1155/2009/173439
spellingShingle R. García-Muñoz
P. Rodríguez-Otero
A. Galar
J. Merino
J. J. Beunza
J. A. Páramo
R. Lecumberri
Expansion of CD8+CD57+ T Cells in an Immunocompetent Patient with Acute Toxoplasmosis
Advances in Hematology
title Expansion of CD8+CD57+ T Cells in an Immunocompetent Patient with Acute Toxoplasmosis
title_full Expansion of CD8+CD57+ T Cells in an Immunocompetent Patient with Acute Toxoplasmosis
title_fullStr Expansion of CD8+CD57+ T Cells in an Immunocompetent Patient with Acute Toxoplasmosis
title_full_unstemmed Expansion of CD8+CD57+ T Cells in an Immunocompetent Patient with Acute Toxoplasmosis
title_short Expansion of CD8+CD57+ T Cells in an Immunocompetent Patient with Acute Toxoplasmosis
title_sort expansion of cd8 cd57 t cells in an immunocompetent patient with acute toxoplasmosis
url http://dx.doi.org/10.1155/2009/173439
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