Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model

Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model

Abstract The ubiquitous opportunistic pathogen Pseudomonas aeruginosa is responsible for severe infections and notoriously known for acquiring antimicrobial resistance. Inhibiting the bacterium's extracellular elastase, LasB – a zinc‐dependent protease – presents a promising strategy to mitigat...

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Main Authors: Alexander F. Kiefer, Christian Schütz, Colya N. Englisch, Dominik Kolling, Samira Speicher, Andreas M. Kany, Roya Shafiei, Noran A. Wadood, Ahmad Aljohmani, Niklas Wirschem, Ravindra P. Jumde, Andreas Klein, Asfandyar Sikandar, Yu‐Mi Park, Gabriela Krasteva‐Christ, Daniela Yildiz, Ahmed S. Abdelsamie, Katharina Rox, Jesko Köhnke, Rolf Müller, Markus Bischoff, Jörg Haupenthal, Anna K. H. Hirsch
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
elastase B
keratitis
phosphonates
Pseudomonas aeruginosa
Online Access:https://doi.org/10.1002/advs.202411807
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