The diagnostic accuracy of urine-derived exosomes for bladder cancer: a systematic review and meta-analysis
Abstract Introduction Urine-derived exosomes could potentially be biomarkers for bladder cancer (BC) diagnosis. This study aimed to systematically evaluate the diagnostic worth of urine-derived exosomes in BC patients through a meta-analysis of diverse studies. Methods A systematic search was carrie...
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BMC
2024-10-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-024-03569-1 |
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| author | Chunyue Long Hongjin Shi Jinyu Li Lijian Chen Mei Lv Wenlin Tai Haifeng Wang Yiheng Xu |
| author_facet | Chunyue Long Hongjin Shi Jinyu Li Lijian Chen Mei Lv Wenlin Tai Haifeng Wang Yiheng Xu |
| author_sort | Chunyue Long |
| collection | DOAJ |
| description | Abstract Introduction Urine-derived exosomes could potentially be biomarkers for bladder cancer (BC) diagnosis. This study aimed to systematically evaluate the diagnostic worth of urine-derived exosomes in BC patients through a meta-analysis of diverse studies. Methods A systematic search was carried out in PubMed, Web of Science, Embase, Cochrane, and CNKI databases to obtain the literature concerning the diagnosis of BC via urine-derived exosomes. A literature retrieval strategy was devised to pick articles and extract needed data from the literature. QUADS-2 was used to evaluate the quality of the included literatures, and the aggregated diagnostic effect was assessed by calculating the area under the aggregated SROC curve. All statistical analyses and plots were conducted with STATA 14.0 and RevMan5.3. Results A total of 678 articles were retrieved by means of the search strategy of the online database. Through screening, 21 articles were obtained, involving 3348 participants and 77 studies. The meta-analysis of the results indicated that urinary exosomes had a combined sensitivity of 0.75, a specificity of 0.77, and a combined AUC of 0.83 for the diagnosis of BC, suggesting that urine-derived exosomes have a relatively satisfactory diagnostic effect in the detection of BC. Among the subgroups classified by biomarker, long non-coding RNAs (lncRNAs) had the highest comprehensive sensitivity (SEN = 0.78), and miRNAs had the highest comprehensive specificity (SPN = 0.81). In other subgroup analyses, the biomarker panel for multiple exosomes combined diagnosis demonstrated the best diagnostic efficacy, with a combined the area under the curve ( AUC) of 0.87. Conclusions As a novel biomarker, urine-derived exosomes have significant diagnostic prospects in the diagnosis of BC. Nevertheless, their application in clinical settings still demands a considerable number of clinical trials to confirm their clinical feasibility and practicability. |
| format | Article |
| id | doaj-art-7e8559e2b4394544a9bffcf0f6286a00 |
| institution | OA Journals |
| issn | 1477-7819 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-7e8559e2b4394544a9bffcf0f6286a002025-08-20T02:18:24ZengBMCWorld Journal of Surgical Oncology1477-78192024-10-0122111610.1186/s12957-024-03569-1The diagnostic accuracy of urine-derived exosomes for bladder cancer: a systematic review and meta-analysisChunyue Long0Hongjin Shi1Jinyu Li2Lijian Chen3Mei Lv4Wenlin Tai5Haifeng Wang6Yiheng Xu7Department of Clinical Laboratory, the Second Affiliated Hospital of Kunming Medical University, Kunming Department of Urology, the Second Affiliated Hospital of Kunming Medical University, Kunming Department of Clinical Laboratory, the Second Affiliated Hospital of Kunming Medical University, Kunming Department of Clinical Laboratory, Fuqing People’s Hospital, Fuqing Department of Clinical Laboratory, the Second Affiliated Hospital of Kunming Medical University, Kunming Department of Clinical Laboratory, the Second Affiliated Hospital of Kunming Medical University, Kunming Department of Urology, the Second Affiliated Hospital of Kunming Medical University, Kunming Department of Clinical Laboratory, the Second Affiliated Hospital of Kunming Medical University, Kunming Abstract Introduction Urine-derived exosomes could potentially be biomarkers for bladder cancer (BC) diagnosis. This study aimed to systematically evaluate the diagnostic worth of urine-derived exosomes in BC patients through a meta-analysis of diverse studies. Methods A systematic search was carried out in PubMed, Web of Science, Embase, Cochrane, and CNKI databases to obtain the literature concerning the diagnosis of BC via urine-derived exosomes. A literature retrieval strategy was devised to pick articles and extract needed data from the literature. QUADS-2 was used to evaluate the quality of the included literatures, and the aggregated diagnostic effect was assessed by calculating the area under the aggregated SROC curve. All statistical analyses and plots were conducted with STATA 14.0 and RevMan5.3. Results A total of 678 articles were retrieved by means of the search strategy of the online database. Through screening, 21 articles were obtained, involving 3348 participants and 77 studies. The meta-analysis of the results indicated that urinary exosomes had a combined sensitivity of 0.75, a specificity of 0.77, and a combined AUC of 0.83 for the diagnosis of BC, suggesting that urine-derived exosomes have a relatively satisfactory diagnostic effect in the detection of BC. Among the subgroups classified by biomarker, long non-coding RNAs (lncRNAs) had the highest comprehensive sensitivity (SEN = 0.78), and miRNAs had the highest comprehensive specificity (SPN = 0.81). In other subgroup analyses, the biomarker panel for multiple exosomes combined diagnosis demonstrated the best diagnostic efficacy, with a combined the area under the curve ( AUC) of 0.87. Conclusions As a novel biomarker, urine-derived exosomes have significant diagnostic prospects in the diagnosis of BC. Nevertheless, their application in clinical settings still demands a considerable number of clinical trials to confirm their clinical feasibility and practicability.https://doi.org/10.1186/s12957-024-03569-1Urine derived exosomesBladder cancerDiagnosisBiomarker |
| spellingShingle | Chunyue Long Hongjin Shi Jinyu Li Lijian Chen Mei Lv Wenlin Tai Haifeng Wang Yiheng Xu The diagnostic accuracy of urine-derived exosomes for bladder cancer: a systematic review and meta-analysis World Journal of Surgical Oncology Urine derived exosomes Bladder cancer Diagnosis Biomarker |
| title | The diagnostic accuracy of urine-derived exosomes for bladder cancer: a systematic review and meta-analysis |
| title_full | The diagnostic accuracy of urine-derived exosomes for bladder cancer: a systematic review and meta-analysis |
| title_fullStr | The diagnostic accuracy of urine-derived exosomes for bladder cancer: a systematic review and meta-analysis |
| title_full_unstemmed | The diagnostic accuracy of urine-derived exosomes for bladder cancer: a systematic review and meta-analysis |
| title_short | The diagnostic accuracy of urine-derived exosomes for bladder cancer: a systematic review and meta-analysis |
| title_sort | diagnostic accuracy of urine derived exosomes for bladder cancer a systematic review and meta analysis |
| topic | Urine derived exosomes Bladder cancer Diagnosis Biomarker |
| url | https://doi.org/10.1186/s12957-024-03569-1 |
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