Gallic Acid Nanocrystal Hydrogel: A Novel Strategy for Promoting Wound Healing and Inhibiting Scar Formation
Mengtong Yan,1– 3,* Sier Huang,1– 3 Xin Li,1– 3 Ying Wang,1– 3,* Shuyi Zhong,4 Junfeng Ban,1– 4 Shu Zhang1– 3 1Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 2Center for Drug Research...
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Dove Medical Press
2025-04-01
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| Series: | International Journal of Nanomedicine |
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| author | Yan M Huang S Li X Wang Y Zhong S Ban J Zhang S |
| author_facet | Yan M Huang S Li X Wang Y Zhong S Ban J Zhang S |
| author_sort | Yan M |
| collection | DOAJ |
| description | Mengtong Yan,1– 3,* Sier Huang,1– 3 Xin Li,1– 3 Ying Wang,1– 3,* Shuyi Zhong,4 Junfeng Ban,1– 4 Shu Zhang1– 3 1Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 2Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 3Guangdong Engineering & Technology Research Center of Topic Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 4The Innovation Team for Integrating Pharmacy with Entrepreneurship, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junfeng Ban, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China, Tel +86 20 39352309, Email banjunfeng@163.com Shu Zhang, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China, Email zzss_97@163.comBackground: Slow healing of skin wounds is a major health problem affecting millions of people each year, and traditional dressings have limited effectiveness in treating them. Gallic acid has anti-inflammatory, antibacterial and antioxidant properties, and combined with nanotechnology can improve its solubility and provide new directions for wound treatment.Methods: In this study, Gallic acid nanocrystals (GC-NCs) were prepared by a “top-down” method, and GC-NCs were combined with a polyacrylic acid matrix to form Gallic acid nanocrystal hydrogel (GC-NCs-Gel) by co-gelation. The micromorphology, mechanical properties, adhesion properties and bioactivity of GC-NCs-Gel were tested. Finally, the ability of GC-NCs-Gel to promote wound healing and inhibit scar formation was evaluated in a rat whole skin defect model.Results: The average particle size of GC-NCs was 348.20 ± 1.42 nm, and GC-NCs-Gel had a honeycomb porous structure with excellent swelling properties (963%), water vapor transmission rate (2400 g/m2/h), tensile stress (28,000 Pa), and adhesive strength (9.6 kPa). GC-NCs-Gel also demonstrated a sustained and controlled drug release property after 48 h of release, the cumulative release was about 57%, and GC-NCs-Gel reached the highest cumulative permeability of 127.2 μg/cm2 within 6 h. In vitro experiments showed that the inhibition circle diameter of GC-NCs-Gel was 39.75 ± 0.61 mm for S. aureus and 21.52 ± 0.06 mm for E. coli. The free radical scavenging efficiency of GC-NCs-Gel reached 77.7% in the DPPH assay and up to 98.6% in ABTS. In vivo experiments showed that GC-NCs-Gel accelerated wound healing by promoting neovascularization, epidermal regeneration and collagen deposition.Conclusion: In this study, a GC-NCs-Gel with anti-inflammatory, antibacterial as well as antioxidant and wound tissue adhesion was prepared. This multi-functional hydrogel has significant advantages in wound healing, and is expected to provide a new and effective means of wound treatment in the clinic. Keywords: gallic acid nanocrystal hydrogel, hydrogel, wound healing, scarring inhibition |
| format | Article |
| id | doaj-art-7e8453c13ecc4d5c866ac6eb2b4888fc |
| institution | OA Journals |
| issn | 1178-2013 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj-art-7e8453c13ecc4d5c866ac6eb2b4888fc2025-08-20T02:16:02ZengDove Medical PressInternational Journal of Nanomedicine1178-20132025-04-01Volume 2046074626102007Gallic Acid Nanocrystal Hydrogel: A Novel Strategy for Promoting Wound Healing and Inhibiting Scar FormationYan MHuang SLi XWang YZhong SBan JZhang SMengtong Yan,1– 3,* Sier Huang,1– 3 Xin Li,1– 3 Ying Wang,1– 3,* Shuyi Zhong,4 Junfeng Ban,1– 4 Shu Zhang1– 3 1Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 2Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 3Guangdong Engineering & Technology Research Center of Topic Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 4The Innovation Team for Integrating Pharmacy with Entrepreneurship, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junfeng Ban, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China, Tel +86 20 39352309, Email banjunfeng@163.com Shu Zhang, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, 510006, People’s Republic of China, Email zzss_97@163.comBackground: Slow healing of skin wounds is a major health problem affecting millions of people each year, and traditional dressings have limited effectiveness in treating them. Gallic acid has anti-inflammatory, antibacterial and antioxidant properties, and combined with nanotechnology can improve its solubility and provide new directions for wound treatment.Methods: In this study, Gallic acid nanocrystals (GC-NCs) were prepared by a “top-down” method, and GC-NCs were combined with a polyacrylic acid matrix to form Gallic acid nanocrystal hydrogel (GC-NCs-Gel) by co-gelation. The micromorphology, mechanical properties, adhesion properties and bioactivity of GC-NCs-Gel were tested. Finally, the ability of GC-NCs-Gel to promote wound healing and inhibit scar formation was evaluated in a rat whole skin defect model.Results: The average particle size of GC-NCs was 348.20 ± 1.42 nm, and GC-NCs-Gel had a honeycomb porous structure with excellent swelling properties (963%), water vapor transmission rate (2400 g/m2/h), tensile stress (28,000 Pa), and adhesive strength (9.6 kPa). GC-NCs-Gel also demonstrated a sustained and controlled drug release property after 48 h of release, the cumulative release was about 57%, and GC-NCs-Gel reached the highest cumulative permeability of 127.2 μg/cm2 within 6 h. In vitro experiments showed that the inhibition circle diameter of GC-NCs-Gel was 39.75 ± 0.61 mm for S. aureus and 21.52 ± 0.06 mm for E. coli. The free radical scavenging efficiency of GC-NCs-Gel reached 77.7% in the DPPH assay and up to 98.6% in ABTS. In vivo experiments showed that GC-NCs-Gel accelerated wound healing by promoting neovascularization, epidermal regeneration and collagen deposition.Conclusion: In this study, a GC-NCs-Gel with anti-inflammatory, antibacterial as well as antioxidant and wound tissue adhesion was prepared. This multi-functional hydrogel has significant advantages in wound healing, and is expected to provide a new and effective means of wound treatment in the clinic. Keywords: gallic acid nanocrystal hydrogel, hydrogel, wound healing, scarring inhibitionhttps://www.dovepress.com/gallic-acid-nanocrystal-hydrogel-a-novel-strategy-for-promoting-wound--peer-reviewed-fulltext-article-IJNgallic acid nanocrystal hydrogelhydrogelwound healingscarring inhibition |
| spellingShingle | Yan M Huang S Li X Wang Y Zhong S Ban J Zhang S Gallic Acid Nanocrystal Hydrogel: A Novel Strategy for Promoting Wound Healing and Inhibiting Scar Formation International Journal of Nanomedicine gallic acid nanocrystal hydrogel hydrogel wound healing scarring inhibition |
| title | Gallic Acid Nanocrystal Hydrogel: A Novel Strategy for Promoting Wound Healing and Inhibiting Scar Formation |
| title_full | Gallic Acid Nanocrystal Hydrogel: A Novel Strategy for Promoting Wound Healing and Inhibiting Scar Formation |
| title_fullStr | Gallic Acid Nanocrystal Hydrogel: A Novel Strategy for Promoting Wound Healing and Inhibiting Scar Formation |
| title_full_unstemmed | Gallic Acid Nanocrystal Hydrogel: A Novel Strategy for Promoting Wound Healing and Inhibiting Scar Formation |
| title_short | Gallic Acid Nanocrystal Hydrogel: A Novel Strategy for Promoting Wound Healing and Inhibiting Scar Formation |
| title_sort | gallic acid nanocrystal hydrogel a novel strategy for promoting wound healing and inhibiting scar formation |
| topic | gallic acid nanocrystal hydrogel hydrogel wound healing scarring inhibition |
| url | https://www.dovepress.com/gallic-acid-nanocrystal-hydrogel-a-novel-strategy-for-promoting-wound--peer-reviewed-fulltext-article-IJN |
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