Impact of Vitamin E Supplementation on High-Density Lipoprotein in Patients With Haptoglobin Genotype–Stratified Diabetes: A Systematic Review of Randomized Controlled Trials

Conclusions: Although vitamin E supplementation did not significantly impact HDL levels in individuals with diabetes of any Hp genotype, it may improve HDL function in individuals with Hp2-2 diabetes. These findings indicate a pharmacogenetic interaction between vitamin E and the Hp genotype on HDL...

Full description

Saved in:
Bibliographic Details
Main Authors: Pan-pan Zheng, Li-wen Zhang, Dan Sheng, Min-zhen Wang, Rong Li, Wei-li Zhao, Rongmei Liu, Xian Xiu, Yu-sha Zhao, Xi Min, Zhi-kai Wang, Zan-chao Liu
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2024/6645595
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850214306475409408
author Pan-pan Zheng
Li-wen Zhang
Dan Sheng
Min-zhen Wang
Rong Li
Wei-li Zhao
Rongmei Liu
Xian Xiu
Yu-sha Zhao
Xi Min
Zhi-kai Wang
Zan-chao Liu
author_facet Pan-pan Zheng
Li-wen Zhang
Dan Sheng
Min-zhen Wang
Rong Li
Wei-li Zhao
Rongmei Liu
Xian Xiu
Yu-sha Zhao
Xi Min
Zhi-kai Wang
Zan-chao Liu
author_sort Pan-pan Zheng
collection DOAJ
description Conclusions: Although vitamin E supplementation did not significantly impact HDL levels in individuals with diabetes of any Hp genotype, it may improve HDL function in individuals with Hp2-2 diabetes. These findings indicate a pharmacogenetic interaction between vitamin E and the Hp genotype on HDL function. Moreover, vitamin E supplementation may be an effective strategy for specific individuals with diabetes.
format Article
id doaj-art-7e8138019fbd40cda46fe8b8f2e0027c
institution OA Journals
issn 2314-6753
language English
publishDate 2024-01-01
publisher Wiley
record_format Article
series Journal of Diabetes Research
spelling doaj-art-7e8138019fbd40cda46fe8b8f2e0027c2025-08-20T02:08:57ZengWileyJournal of Diabetes Research2314-67532024-01-01202410.1155/2024/6645595Impact of Vitamin E Supplementation on High-Density Lipoprotein in Patients With Haptoglobin Genotype–Stratified Diabetes: A Systematic Review of Randomized Controlled TrialsPan-pan Zheng0Li-wen Zhang1Dan Sheng2Min-zhen Wang3Rong Li4Wei-li Zhao5Rongmei Liu6Xian Xiu7Yu-sha Zhao8Xi Min9Zhi-kai Wang10Zan-chao Liu11Hebei Key Laboratory of Basic Medicine for DiabetesHebei Key Laboratory of Environment and Human HealthInstitute of Epidemiology and Health StatisticsInstitute of Epidemiology and Health StatisticsHebei Key Laboratory of Basic Medicine for DiabetesShijiazhuang Technology Innovation Center of Precision Medicine for DiabetesShijiazhuang Technology Innovation Center of Precision Medicine for DiabetesShijiazhuang Technology Innovation Center of Precision Medicine for DiabetesShijiazhuang Technology Innovation Center of Precision Medicine for DiabetesDepartment of Clinical LaboratoriesSchool of Clinical MedicineHebei Key Laboratory of Basic Medicine for DiabetesConclusions: Although vitamin E supplementation did not significantly impact HDL levels in individuals with diabetes of any Hp genotype, it may improve HDL function in individuals with Hp2-2 diabetes. These findings indicate a pharmacogenetic interaction between vitamin E and the Hp genotype on HDL function. Moreover, vitamin E supplementation may be an effective strategy for specific individuals with diabetes.http://dx.doi.org/10.1155/2024/6645595
spellingShingle Pan-pan Zheng
Li-wen Zhang
Dan Sheng
Min-zhen Wang
Rong Li
Wei-li Zhao
Rongmei Liu
Xian Xiu
Yu-sha Zhao
Xi Min
Zhi-kai Wang
Zan-chao Liu
Impact of Vitamin E Supplementation on High-Density Lipoprotein in Patients With Haptoglobin Genotype–Stratified Diabetes: A Systematic Review of Randomized Controlled Trials
Journal of Diabetes Research
title Impact of Vitamin E Supplementation on High-Density Lipoprotein in Patients With Haptoglobin Genotype–Stratified Diabetes: A Systematic Review of Randomized Controlled Trials
title_full Impact of Vitamin E Supplementation on High-Density Lipoprotein in Patients With Haptoglobin Genotype–Stratified Diabetes: A Systematic Review of Randomized Controlled Trials
title_fullStr Impact of Vitamin E Supplementation on High-Density Lipoprotein in Patients With Haptoglobin Genotype–Stratified Diabetes: A Systematic Review of Randomized Controlled Trials
title_full_unstemmed Impact of Vitamin E Supplementation on High-Density Lipoprotein in Patients With Haptoglobin Genotype–Stratified Diabetes: A Systematic Review of Randomized Controlled Trials
title_short Impact of Vitamin E Supplementation on High-Density Lipoprotein in Patients With Haptoglobin Genotype–Stratified Diabetes: A Systematic Review of Randomized Controlled Trials
title_sort impact of vitamin e supplementation on high density lipoprotein in patients with haptoglobin genotype stratified diabetes a systematic review of randomized controlled trials
url http://dx.doi.org/10.1155/2024/6645595
work_keys_str_mv AT panpanzheng impactofvitaminesupplementationonhighdensitylipoproteininpatientswithhaptoglobingenotypestratifieddiabetesasystematicreviewofrandomizedcontrolledtrials
AT liwenzhang impactofvitaminesupplementationonhighdensitylipoproteininpatientswithhaptoglobingenotypestratifieddiabetesasystematicreviewofrandomizedcontrolledtrials
AT dansheng impactofvitaminesupplementationonhighdensitylipoproteininpatientswithhaptoglobingenotypestratifieddiabetesasystematicreviewofrandomizedcontrolledtrials
AT minzhenwang impactofvitaminesupplementationonhighdensitylipoproteininpatientswithhaptoglobingenotypestratifieddiabetesasystematicreviewofrandomizedcontrolledtrials
AT rongli impactofvitaminesupplementationonhighdensitylipoproteininpatientswithhaptoglobingenotypestratifieddiabetesasystematicreviewofrandomizedcontrolledtrials
AT weilizhao impactofvitaminesupplementationonhighdensitylipoproteininpatientswithhaptoglobingenotypestratifieddiabetesasystematicreviewofrandomizedcontrolledtrials
AT rongmeiliu impactofvitaminesupplementationonhighdensitylipoproteininpatientswithhaptoglobingenotypestratifieddiabetesasystematicreviewofrandomizedcontrolledtrials
AT xianxiu impactofvitaminesupplementationonhighdensitylipoproteininpatientswithhaptoglobingenotypestratifieddiabetesasystematicreviewofrandomizedcontrolledtrials
AT yushazhao impactofvitaminesupplementationonhighdensitylipoproteininpatientswithhaptoglobingenotypestratifieddiabetesasystematicreviewofrandomizedcontrolledtrials
AT ximin impactofvitaminesupplementationonhighdensitylipoproteininpatientswithhaptoglobingenotypestratifieddiabetesasystematicreviewofrandomizedcontrolledtrials
AT zhikaiwang impactofvitaminesupplementationonhighdensitylipoproteininpatientswithhaptoglobingenotypestratifieddiabetesasystematicreviewofrandomizedcontrolledtrials
AT zanchaoliu impactofvitaminesupplementationonhighdensitylipoproteininpatientswithhaptoglobingenotypestratifieddiabetesasystematicreviewofrandomizedcontrolledtrials