CCR8 antagonist suppresses liver cancer progression via turning tumor-infiltrating Tregs into less immunosuppressive phenotype

CCR8 antagonist suppresses liver cancer progression via turning tumor-infiltrating Tregs into less immunosuppressive phenotype

Abstract Background Regulatory T cells (Tregs) are the main immunosuppressive cells in tumor immune microenvironment (TIME). However, systemic Treg depletion is not favored due to the crucial role of Tregs in the maintenance of immune homeostasis and prevention of autoimmunity. Recently, CCR8 has be...

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Main Authors: Binle Tian, Zhilong Wang, Mei Cao, Na Wang, Xuebing Jia, Yuanyuan Zhang, Jingyi Zhou, Sijia Liu, Wen Zhang, Xiao Dong, Zheng Li, Junli Xue, JianFei Wang, Guo-Huang Fan, Qi Li
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
CCR8
IPG0521m
Tregs
Liver cancer
Single-cell sequencing
Tumor microenvironment
Online Access:https://doi.org/10.1186/s13046-025-03286-x
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