Synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery
Abstract This study presents a novel synbiotic yogurt fortified with free and PLGA-entrapped rice straw hemicellulose hydrolyzate (RSHH) to offer immediate probiotic support and sustained prebiotic delivery. RSHH, obtained by enzymatic hydrolysis, yielded 0.5 g/g hemicellulose and was rich in xylool...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-025-00539-z |
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| author | Shaymaa A. Ismail Bahgat Fayed Hoda S. El-Sayed Hanan A. A. Taie Amira A. Hassan |
| author_facet | Shaymaa A. Ismail Bahgat Fayed Hoda S. El-Sayed Hanan A. A. Taie Amira A. Hassan |
| author_sort | Shaymaa A. Ismail |
| collection | DOAJ |
| description | Abstract This study presents a novel synbiotic yogurt fortified with free and PLGA-entrapped rice straw hemicellulose hydrolyzate (RSHH) to offer immediate probiotic support and sustained prebiotic delivery. RSHH, obtained by enzymatic hydrolysis, yielded 0.5 g/g hemicellulose and was rich in xylooligosaccharides (48.3% reducing sugars), with notable antioxidant activity (45.59 µmol Trolox/mg) and anticancer effects (61.98% reduction in EAC cell viability at 1000 µg/mL). It enhanced the growth of Lactiplantibacillus paraplantarum and Bifidobacterium bifidum more effectively than inulin. Biosafety tests in rats confirmed no adverse effects and improved lipid profiles. RSHH was successfully encapsulated into PLGA nanoparticles (38.77% efficiency, 204.9 nm size, –18.3 mV zeta potential), with spherical morphology, uniform distribution and no aggregation as confirmed by TEM. Yogurt containing both free and entrapped RSHH demonstrated the best performance over 20 days. This dual-delivery system offers a promising solution to enhance probiotic viability and prebiotic stability in functional food applications. |
| format | Article |
| id | doaj-art-7e78b6f94db94fa794bbb30b34f77149 |
| institution | Kabale University |
| issn | 2396-8370 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-7e78b6f94db94fa794bbb30b34f771492025-08-24T11:52:56ZengNature Portfolionpj Science of Food2396-83702025-08-019111210.1038/s41538-025-00539-zSynbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic deliveryShaymaa A. Ismail0Bahgat Fayed1Hoda S. El-Sayed2Hanan A. A. Taie3Amira A. Hassan4Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research CentreDepartment of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research CentreDairy Department, Food Industries and Nutrition Research Institute, National Research CentrePlant Biochemistry Department, Agricultural and Biology Research Institute, National Research CentreDepartment of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research CentreAbstract This study presents a novel synbiotic yogurt fortified with free and PLGA-entrapped rice straw hemicellulose hydrolyzate (RSHH) to offer immediate probiotic support and sustained prebiotic delivery. RSHH, obtained by enzymatic hydrolysis, yielded 0.5 g/g hemicellulose and was rich in xylooligosaccharides (48.3% reducing sugars), with notable antioxidant activity (45.59 µmol Trolox/mg) and anticancer effects (61.98% reduction in EAC cell viability at 1000 µg/mL). It enhanced the growth of Lactiplantibacillus paraplantarum and Bifidobacterium bifidum more effectively than inulin. Biosafety tests in rats confirmed no adverse effects and improved lipid profiles. RSHH was successfully encapsulated into PLGA nanoparticles (38.77% efficiency, 204.9 nm size, –18.3 mV zeta potential), with spherical morphology, uniform distribution and no aggregation as confirmed by TEM. Yogurt containing both free and entrapped RSHH demonstrated the best performance over 20 days. This dual-delivery system offers a promising solution to enhance probiotic viability and prebiotic stability in functional food applications.https://doi.org/10.1038/s41538-025-00539-z |
| spellingShingle | Shaymaa A. Ismail Bahgat Fayed Hoda S. El-Sayed Hanan A. A. Taie Amira A. Hassan Synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery npj Science of Food |
| title | Synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery |
| title_full | Synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery |
| title_fullStr | Synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery |
| title_full_unstemmed | Synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery |
| title_short | Synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery |
| title_sort | synbiotic yogurt with nanoparticle entrapped rice straw hemicellulose for immediate probiotic support and prebiotic delivery |
| url | https://doi.org/10.1038/s41538-025-00539-z |
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