Exercise Promotes Hippocampal Neurogenesis in T2DM Mice via Irisin/TLR4/MyD88/NF-κB-Mediated Neuroinflammation Pathway

Exercise Promotes Hippocampal Neurogenesis in T2DM Mice via Irisin/TLR4/MyD88/NF-κB-Mediated Neuroinflammation Pathway

Neuroinflammation is a major feature of type 2 diabetic mellitus (T2DM), adversely affecting hippocampal neurogenesis. However, the precise mechanism is not fully understood, and therapeutic approaches are currently lacking. Therefore, we determined the effects of exercise on neuroinflammation and h...

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Bibliographic Details
Main Authors: Haocheng Xu, Xin Tian, Yuanxin Wang, Junjie Lin, Baishu Zhu, Chen Zhao, Bin Wang, Xin Zhang, Yu Sun, Nan Li, Xun Sun, Fanxi Zeng, Mingzhi Li, Xiquan Ya, Renqing Zhao
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Biology
Subjects:
diabetes
cognition
adult hippocampal neurogenesis
exercise
neuroinflammation
Online Access:https://www.mdpi.com/2079-7737/13/10/809
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