Mechanism of DNA degradation by CBASS Cap5 endonuclease immune effector

Mechanism of DNA degradation by CBASS Cap5 endonuclease immune effector

Abstract Bacterial CBASS immune defense systems commonly kill virally infected cells by degrading genomic DNA in a form of cell suicide or abortive infection. We present a high-resolution structure of the CBASS effector Cap5, activated by a cyclic nucleotide, in the act of digesting DNA via tetramer...

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Bibliographic Details
Main Authors: Olga Rechkoblit, Daniela Sciaky, Mi Ni, Yangmei Li, Jithesh Kottur, Gang Fang, Aneel K. Aggarwal
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60484-z
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