The effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms: a systematic review and meta-analysis
Vaginal dryness and dyspareunia are frequent complaints among postmenopausal women. Studies have shown that isoflavones reduce the severity of menopausal symptoms. This study aimed to evaluate the effects of isoflavones on vaginal dryness and dyspareunia in postmenopausal women. PubMed, ScienceDirec...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Obstetrics and Gynecology
2025-03-01
|
| Series: | Obstetrics & Gynecology Science |
| Subjects: | |
| Online Access: | http://www.ogscience.org/upload/pdf/ogs-24282.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849733594285604864 |
|---|---|
| author | Tri Hastono Setyo Hadi Budi Santoso Gatut Hardianto Eighty Mardiyan Kurniawati |
| author_facet | Tri Hastono Setyo Hadi Budi Santoso Gatut Hardianto Eighty Mardiyan Kurniawati |
| author_sort | Tri Hastono Setyo Hadi |
| collection | DOAJ |
| description | Vaginal dryness and dyspareunia are frequent complaints among postmenopausal women. Studies have shown that isoflavones reduce the severity of menopausal symptoms. This study aimed to evaluate the effects of isoflavones on vaginal dryness and dyspareunia in postmenopausal women. PubMed, ScienceDirect, and Cochrane Library electronic databases were searched until June 15, 2024. Revman 5.4 software (The Nordic Cochrane Centre, Copenhagen, Denmark) was used to analyze the data. Ten randomized controlled trials (RCTs), totaling 675 participants, were included in the isoflavone treatment, and the duration was between 4 and 48 weeks. For the meta-analysis, four and two RCTs were conducted to analyze vaginal dryness and dyspareunia in postmenopausal women before and after isoflavone treatment, respectively. The analysis results for vaginal dryness showed a significant change after isoflavone therapy, whereas those for dyspareunia did not show a significant change. The random-effects estimation of the mean difference was −1.29, and 95% confidence interval (CI) was −2.53 to −0.04 (P=0.04) for vaginal dryness, and −0.82, with a 95% CI of −3.51 to 1.87 (P=0.55) for dyspareunia. This meta-analysis concluded that isoflavones have a significant effect on relieving vaginal dryness but have no impact on dyspareunia in postmenopausal women. Numerous larger, long-term trials are needed to fully assess their effects and efficacy. |
| format | Article |
| id | doaj-art-7e6e1906cfb948d1ae01266a3d712a39 |
| institution | DOAJ |
| issn | 2287-8572 2287-8580 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj-art-7e6e1906cfb948d1ae01266a3d712a392025-08-20T03:08:00ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802025-03-0168213113810.5468/ogs.242828864The effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms: a systematic review and meta-analysisTri Hastono Setyo Hadi0Budi Santoso1Gatut Hardianto2Eighty Mardiyan Kurniawati3 Doctoral Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia Department of Obstetrics and Gynecology, Dr. Soetomo General Academic Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia Department of Obstetrics and Gynecology, Dr. Soetomo General Academic Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia Department of Obstetrics and Gynecology, Dr. Soetomo General Academic Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaVaginal dryness and dyspareunia are frequent complaints among postmenopausal women. Studies have shown that isoflavones reduce the severity of menopausal symptoms. This study aimed to evaluate the effects of isoflavones on vaginal dryness and dyspareunia in postmenopausal women. PubMed, ScienceDirect, and Cochrane Library electronic databases were searched until June 15, 2024. Revman 5.4 software (The Nordic Cochrane Centre, Copenhagen, Denmark) was used to analyze the data. Ten randomized controlled trials (RCTs), totaling 675 participants, were included in the isoflavone treatment, and the duration was between 4 and 48 weeks. For the meta-analysis, four and two RCTs were conducted to analyze vaginal dryness and dyspareunia in postmenopausal women before and after isoflavone treatment, respectively. The analysis results for vaginal dryness showed a significant change after isoflavone therapy, whereas those for dyspareunia did not show a significant change. The random-effects estimation of the mean difference was −1.29, and 95% confidence interval (CI) was −2.53 to −0.04 (P=0.04) for vaginal dryness, and −0.82, with a 95% CI of −3.51 to 1.87 (P=0.55) for dyspareunia. This meta-analysis concluded that isoflavones have a significant effect on relieving vaginal dryness but have no impact on dyspareunia in postmenopausal women. Numerous larger, long-term trials are needed to fully assess their effects and efficacy.http://www.ogscience.org/upload/pdf/ogs-24282.pdfisoflavoneflavonoidpostmenopauseatrophic vaginitisdyspareunia |
| spellingShingle | Tri Hastono Setyo Hadi Budi Santoso Gatut Hardianto Eighty Mardiyan Kurniawati The effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms: a systematic review and meta-analysis Obstetrics & Gynecology Science isoflavone flavonoid postmenopause atrophic vaginitis dyspareunia |
| title | The effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms: a systematic review and meta-analysis |
| title_full | The effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms: a systematic review and meta-analysis |
| title_fullStr | The effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms: a systematic review and meta-analysis |
| title_full_unstemmed | The effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms: a systematic review and meta-analysis |
| title_short | The effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms: a systematic review and meta-analysis |
| title_sort | effect of isoflavone on vaginal dryness and dyspareunia in postmenopausal symptoms a systematic review and meta analysis |
| topic | isoflavone flavonoid postmenopause atrophic vaginitis dyspareunia |
| url | http://www.ogscience.org/upload/pdf/ogs-24282.pdf |
| work_keys_str_mv | AT trihastonosetyohadi theeffectofisoflavoneonvaginaldrynessanddyspareuniainpostmenopausalsymptomsasystematicreviewandmetaanalysis AT budisantoso theeffectofisoflavoneonvaginaldrynessanddyspareuniainpostmenopausalsymptomsasystematicreviewandmetaanalysis AT gatuthardianto theeffectofisoflavoneonvaginaldrynessanddyspareuniainpostmenopausalsymptomsasystematicreviewandmetaanalysis AT eightymardiyankurniawati theeffectofisoflavoneonvaginaldrynessanddyspareuniainpostmenopausalsymptomsasystematicreviewandmetaanalysis AT trihastonosetyohadi effectofisoflavoneonvaginaldrynessanddyspareuniainpostmenopausalsymptomsasystematicreviewandmetaanalysis AT budisantoso effectofisoflavoneonvaginaldrynessanddyspareuniainpostmenopausalsymptomsasystematicreviewandmetaanalysis AT gatuthardianto effectofisoflavoneonvaginaldrynessanddyspareuniainpostmenopausalsymptomsasystematicreviewandmetaanalysis AT eightymardiyankurniawati effectofisoflavoneonvaginaldrynessanddyspareuniainpostmenopausalsymptomsasystematicreviewandmetaanalysis |