RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER

RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER

Cancer cells with the loss of BRCA 1 or BRCA 2 function are unable to repair DNA double-strand breaks and demonstrate the increased sensitivity to various DNA-damaging agents. We aimed to describe successful treatment outcomes in two patients with BRCA1-associated ovarian cancer, who showed a comple...

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Bibliographic Details
Main Authors: T. V. Gorodnova, S. B. Baranov, L. N. Shevkunov, S. A. Tyatkov, A. P. Sokolenko, C. B. Kotiv, E. N. Imyanitov, I. V. Berlev
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2017-09-01
Series:Сибирский онкологический журнал
Subjects:
ovarian cancer
dna repair
platinum-based chemotherapy
radiotherapy
Online Access:https://www.siboncoj.ru/jour/article/view/576
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