RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER
Cancer cells with the loss of BRCA 1 or BRCA 2 function are unable to repair DNA double-strand breaks and demonstrate the increased sensitivity to various DNA-damaging agents. We aimed to describe successful treatment outcomes in two patients with BRCA1-associated ovarian cancer, who showed a comple...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2017-09-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/576 |
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| _version_ | 1849699925544140800 |
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| author | T. V. Gorodnova S. B. Baranov L. N. Shevkunov S. A. Tyatkov A. P. Sokolenko C. B. Kotiv E. N. Imyanitov I. V. Berlev |
| author_facet | T. V. Gorodnova S. B. Baranov L. N. Shevkunov S. A. Tyatkov A. P. Sokolenko C. B. Kotiv E. N. Imyanitov I. V. Berlev |
| author_sort | T. V. Gorodnova |
| collection | DOAJ |
| description | Cancer cells with the loss of BRCA 1 or BRCA 2 function are unable to repair DNA double-strand breaks and demonstrate the increased sensitivity to various DNA-damaging agents. We aimed to describe successful treatment outcomes in two patients with BRCA1-associated ovarian cancer, who showed a complete clinical response to radiotherapy in combination with platinum-based chemotherapy. The progression-free survival was 11 months in one case and 8 months in another case. |
| format | Article |
| id | doaj-art-7e672b4d0b494e9d9f9b13c5b596194a |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2017-09-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-7e672b4d0b494e9d9f9b13c5b596194a2025-08-20T03:18:26ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682017-09-0116410310710.21294/1814-4861-2017-16-4-103-107474RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCERT. V. Gorodnova0S. B. Baranov1L. N. Shevkunov2S. A. Tyatkov3A. P. Sokolenko4C. B. Kotiv5E. N. Imyanitov6I. V. Berlev7N.N. Petrov Research Institute of Oncology, Saint-Petersburg.N.N. Petrov Research Institute of Oncology, Saint-Petersburg.N.N. Petrov Research Institute of Oncology, Saint-Petersburg.N.N. Petrov Research Institute of Oncology, Saint-Petersburg.N.N. Petrov Research Institute of Oncology, Saint-Petersburg.N.N. Petrov Research Institute of Oncology, Saint-Petersburg.N.N. Petrov Research Institute of Oncology, Saint-Petersburg.N.N. Petrov Research Institute of Oncology, Saint-Petersburg.Cancer cells with the loss of BRCA 1 or BRCA 2 function are unable to repair DNA double-strand breaks and demonstrate the increased sensitivity to various DNA-damaging agents. We aimed to describe successful treatment outcomes in two patients with BRCA1-associated ovarian cancer, who showed a complete clinical response to radiotherapy in combination with platinum-based chemotherapy. The progression-free survival was 11 months in one case and 8 months in another case.https://www.siboncoj.ru/jour/article/view/576ovarian cancerdna repairplatinum-based chemotherapyradiotherapy |
| spellingShingle | T. V. Gorodnova S. B. Baranov L. N. Shevkunov S. A. Tyatkov A. P. Sokolenko C. B. Kotiv E. N. Imyanitov I. V. Berlev RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER Сибирский онкологический журнал ovarian cancer dna repair platinum-based chemotherapy radiotherapy |
| title | RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER |
| title_full | RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER |
| title_fullStr | RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER |
| title_full_unstemmed | RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER |
| title_short | RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER |
| title_sort | radiotherapy in management of brca positive ovarian cancer |
| topic | ovarian cancer dna repair platinum-based chemotherapy radiotherapy |
| url | https://www.siboncoj.ru/jour/article/view/576 |
| work_keys_str_mv | AT tvgorodnova radiotherapyinmanagementofbrcapositiveovariancancer AT sbbaranov radiotherapyinmanagementofbrcapositiveovariancancer AT lnshevkunov radiotherapyinmanagementofbrcapositiveovariancancer AT satyatkov radiotherapyinmanagementofbrcapositiveovariancancer AT apsokolenko radiotherapyinmanagementofbrcapositiveovariancancer AT cbkotiv radiotherapyinmanagementofbrcapositiveovariancancer AT enimyanitov radiotherapyinmanagementofbrcapositiveovariancancer AT ivberlev radiotherapyinmanagementofbrcapositiveovariancancer |