Optimal sigmoid function models for analysis of transspinal evoked potential recruitment curves recorded from different muscles.

Recruitment input-output curves of transspinal evoked potentials that represent the net output of spinal neuronal networks during which cortical, spinal and peripheral inputs are integrated as well as motor evoked potentials and H-reflexes are used extensively in research as neurophysiological bioma...

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Main Authors: Andreas Skiadopoulos, Maria Knikou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0317218
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author Andreas Skiadopoulos
Maria Knikou
author_facet Andreas Skiadopoulos
Maria Knikou
author_sort Andreas Skiadopoulos
collection DOAJ
description Recruitment input-output curves of transspinal evoked potentials that represent the net output of spinal neuronal networks during which cortical, spinal and peripheral inputs are integrated as well as motor evoked potentials and H-reflexes are used extensively in research as neurophysiological biomarkers to establish physiological or pathological motor behavior and post-treatment recovery. A comparison between different sigmoidal models to fit the transspinal evoked potentials recruitment curve and estimate the parameters of physiological importance has not been performed. This study sought to address this gap by fitting eight sigmoidal models (Boltzmann, Hill, Log-Logistic, Log-Normal, Weibull-1, Weibull-2, Gompertz, Extreme Value Function) to the transspinal evoked potentials recruitment curves of soleus and tibialis anterior recorded under four different cathodal stimulation settings. The sigmoidal models were ranked based on the Akaike information criterion, and their performance was assessed in terms of Akaike differences and weights values. Additionally, an interclass correlation coefficient between the predicted parameters derived from the best models fitted to the recruitment curves was also established. A Bland-Altman analysis was conducted to evaluate the agreement between the predicted parameters from the best models. The findings revealed a muscle dependency, with the Boltzmann and Hill models identified as the best fits for the soleus, while the Extreme Value Function and Boltzmann models were optimal for the tibialis anterior transspinal evoked potentials recruitment curves. Excellent agreement for the upper asymptote, slope, and inflection point parameters was found between Boltzmann and Hill models for the soleus, and for the slope and inflection point parameters between Extreme Value Function and Boltzmann models for the tibialis anterior. Notably, the Boltzmann model for soleus and the Extreme Value Function model for tibialis anterior exhibited less susceptibility to inaccuracies in estimated parameters. Based on these findings, we suggest the Boltzmann and the Extreme Value Function models for fitting the soleus and the tibialis anterior transspinal evoked potentials recruitment curve, respectively.
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spelling doaj-art-7e5dfac5d2aa4ad79cdd7ee7df4a08d92025-02-05T05:31:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031721810.1371/journal.pone.0317218Optimal sigmoid function models for analysis of transspinal evoked potential recruitment curves recorded from different muscles.Andreas SkiadopoulosMaria KnikouRecruitment input-output curves of transspinal evoked potentials that represent the net output of spinal neuronal networks during which cortical, spinal and peripheral inputs are integrated as well as motor evoked potentials and H-reflexes are used extensively in research as neurophysiological biomarkers to establish physiological or pathological motor behavior and post-treatment recovery. A comparison between different sigmoidal models to fit the transspinal evoked potentials recruitment curve and estimate the parameters of physiological importance has not been performed. This study sought to address this gap by fitting eight sigmoidal models (Boltzmann, Hill, Log-Logistic, Log-Normal, Weibull-1, Weibull-2, Gompertz, Extreme Value Function) to the transspinal evoked potentials recruitment curves of soleus and tibialis anterior recorded under four different cathodal stimulation settings. The sigmoidal models were ranked based on the Akaike information criterion, and their performance was assessed in terms of Akaike differences and weights values. Additionally, an interclass correlation coefficient between the predicted parameters derived from the best models fitted to the recruitment curves was also established. A Bland-Altman analysis was conducted to evaluate the agreement between the predicted parameters from the best models. The findings revealed a muscle dependency, with the Boltzmann and Hill models identified as the best fits for the soleus, while the Extreme Value Function and Boltzmann models were optimal for the tibialis anterior transspinal evoked potentials recruitment curves. Excellent agreement for the upper asymptote, slope, and inflection point parameters was found between Boltzmann and Hill models for the soleus, and for the slope and inflection point parameters between Extreme Value Function and Boltzmann models for the tibialis anterior. Notably, the Boltzmann model for soleus and the Extreme Value Function model for tibialis anterior exhibited less susceptibility to inaccuracies in estimated parameters. Based on these findings, we suggest the Boltzmann and the Extreme Value Function models for fitting the soleus and the tibialis anterior transspinal evoked potentials recruitment curve, respectively.https://doi.org/10.1371/journal.pone.0317218
spellingShingle Andreas Skiadopoulos
Maria Knikou
Optimal sigmoid function models for analysis of transspinal evoked potential recruitment curves recorded from different muscles.
PLoS ONE
title Optimal sigmoid function models for analysis of transspinal evoked potential recruitment curves recorded from different muscles.
title_full Optimal sigmoid function models for analysis of transspinal evoked potential recruitment curves recorded from different muscles.
title_fullStr Optimal sigmoid function models for analysis of transspinal evoked potential recruitment curves recorded from different muscles.
title_full_unstemmed Optimal sigmoid function models for analysis of transspinal evoked potential recruitment curves recorded from different muscles.
title_short Optimal sigmoid function models for analysis of transspinal evoked potential recruitment curves recorded from different muscles.
title_sort optimal sigmoid function models for analysis of transspinal evoked potential recruitment curves recorded from different muscles
url https://doi.org/10.1371/journal.pone.0317218
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AT mariaknikou optimalsigmoidfunctionmodelsforanalysisoftransspinalevokedpotentialrecruitmentcurvesrecordedfromdifferentmuscles