Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease
Primary abnormalities of the autonomic nervous system had been postulated as the pathogenic mechanisms of myocardial damage, in patients with Chagas disease. However, recent investigations indicate that these abnormalities are secondary and amenable to treatment with beta-adrenergic blockers. Moreov...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2012/980739 |
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| author | Diego F. Dávila Jose H. Donis Gabriela Arata de Bellabarba Vanesa Villarroel Francisco Sanchez Lisbeth Berrueta Siham Salmen Barbara Das Neves |
| author_facet | Diego F. Dávila Jose H. Donis Gabriela Arata de Bellabarba Vanesa Villarroel Francisco Sanchez Lisbeth Berrueta Siham Salmen Barbara Das Neves |
| author_sort | Diego F. Dávila |
| collection | DOAJ |
| description | Primary abnormalities of the autonomic nervous system had been postulated as the pathogenic mechanisms of myocardial damage, in patients with Chagas disease. However, recent investigations indicate that these abnormalities are secondary and amenable to treatment with beta-adrenergic blockers. Moreover, muscarinic cardiac autoantibodies appear to enhance parasympathetic activity on the sinus node. Therefore, the purpose of this paper is to analyze how knowledge on Chagas' disease evolved from being initially considered as a primary cardioneuromyopathy to the current status of a congestive cardiomyopathy of parasitic origin. |
| format | Article |
| id | doaj-art-7e582ea46fdd4501a586f6083c22b3ca |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-7e582ea46fdd4501a586f6083c22b3ca2025-02-03T01:27:12ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982012-01-01201210.1155/2012/980739980739Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart DiseaseDiego F. Dávila0Jose H. Donis1Gabriela Arata de Bellabarba2Vanesa Villarroel3Francisco Sanchez4Lisbeth Berrueta5Siham Salmen6Barbara Das Neves7Instituto de Investigaciones Cardiovasculares, Departamento de Fisiopatología, Instituto de Inmunologìa Clinica, Facultad de Medicina, Hospital Universitario de Los Andes, Universidad de Los Andes, Mérida 5101, VenezuelaInstituto de Investigaciones Cardiovasculares, Departamento de Fisiopatología, Instituto de Inmunologìa Clinica, Facultad de Medicina, Hospital Universitario de Los Andes, Universidad de Los Andes, Mérida 5101, VenezuelaInstituto de Investigaciones Cardiovasculares, Departamento de Fisiopatología, Instituto de Inmunologìa Clinica, Facultad de Medicina, Hospital Universitario de Los Andes, Universidad de Los Andes, Mérida 5101, VenezuelaInstituto de Investigaciones Cardiovasculares, Departamento de Fisiopatología, Instituto de Inmunologìa Clinica, Facultad de Medicina, Hospital Universitario de Los Andes, Universidad de Los Andes, Mérida 5101, VenezuelaInstituto de Investigaciones Cardiovasculares, Departamento de Fisiopatología, Instituto de Inmunologìa Clinica, Facultad de Medicina, Hospital Universitario de Los Andes, Universidad de Los Andes, Mérida 5101, VenezuelaInstituto de Investigaciones Cardiovasculares, Departamento de Fisiopatología, Instituto de Inmunologìa Clinica, Facultad de Medicina, Hospital Universitario de Los Andes, Universidad de Los Andes, Mérida 5101, VenezuelaInstituto de Investigaciones Cardiovasculares, Departamento de Fisiopatología, Instituto de Inmunologìa Clinica, Facultad de Medicina, Hospital Universitario de Los Andes, Universidad de Los Andes, Mérida 5101, VenezuelaInstituto de Investigaciones Cardiovasculares, Departamento de Fisiopatología, Instituto de Inmunologìa Clinica, Facultad de Medicina, Hospital Universitario de Los Andes, Universidad de Los Andes, Mérida 5101, VenezuelaPrimary abnormalities of the autonomic nervous system had been postulated as the pathogenic mechanisms of myocardial damage, in patients with Chagas disease. However, recent investigations indicate that these abnormalities are secondary and amenable to treatment with beta-adrenergic blockers. Moreover, muscarinic cardiac autoantibodies appear to enhance parasympathetic activity on the sinus node. Therefore, the purpose of this paper is to analyze how knowledge on Chagas' disease evolved from being initially considered as a primary cardioneuromyopathy to the current status of a congestive cardiomyopathy of parasitic origin.http://dx.doi.org/10.1155/2012/980739 |
| spellingShingle | Diego F. Dávila Jose H. Donis Gabriela Arata de Bellabarba Vanesa Villarroel Francisco Sanchez Lisbeth Berrueta Siham Salmen Barbara Das Neves Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease Interdisciplinary Perspectives on Infectious Diseases |
| title | Cardiac Autonomic Control Mechanisms in the Pathogenesis of
Chagas' Heart Disease |
| title_full | Cardiac Autonomic Control Mechanisms in the Pathogenesis of
Chagas' Heart Disease |
| title_fullStr | Cardiac Autonomic Control Mechanisms in the Pathogenesis of
Chagas' Heart Disease |
| title_full_unstemmed | Cardiac Autonomic Control Mechanisms in the Pathogenesis of
Chagas' Heart Disease |
| title_short | Cardiac Autonomic Control Mechanisms in the Pathogenesis of
Chagas' Heart Disease |
| title_sort | cardiac autonomic control mechanisms in the pathogenesis of chagas heart disease |
| url | http://dx.doi.org/10.1155/2012/980739 |
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