Incidence, clinical features and survival among patients with functional pancreatic neuroendrocrine tumors
Introduction: Neuroendocrine tumors (NET) are rare neoplasms derived from neuroendocrine cells that have the ability to synthesize biogenic amines and peptide hormones. Lungs, small and large intestine and pancreas are the most common localizations of these tumors. Depending on the existence of the...
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University of Belgrade, Medical Faculty
2024-01-01
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| Series: | Medicinski Podmladak |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2024/0369-15272406054M.pdf |
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| author | Mijušković Ana Čamur Viktor Popović Bojana |
| author_facet | Mijušković Ana Čamur Viktor Popović Bojana |
| author_sort | Mijušković Ana |
| collection | DOAJ |
| description | Introduction: Neuroendocrine tumors (NET) are rare neoplasms derived from neuroendocrine cells that have the ability to synthesize biogenic amines and peptide hormones. Lungs, small and large intestine and pancreas are the most common localizations of these tumors. Depending on the existence of the hormone secretory syndrome and its clinical manifestations, NETs are divided into functional and non-functional tumors. Aim: The aim of this study was to investigate the incidence, biological behavior and survival of patients with functional pancreatic neuroendocrine tumors. Material and methods: We analyzed 272 patients diagnosed with pancreatic NET. Tumor grade was evaluated based on pathohistological characteristics of the tissue samples obtained by biopsy or surgery, while stage was determined based on the size of the primary tumor and the presence of locoregional and/or distant dissemination. Diagnoses were established by using indicative clinical presentations and by determining baseline hormone values, appropriate functional testing and immunohistochemical confirmation of the secretory product in the tumor tissue sample. Results: Among 272 retrospectively analyzed patients, 77.6% of patients had non-functional tumors, while functional tumors were found in 22.4% cases. Functional NETs were significantly smaller and had a lower tumor grade, as well as significantly lower frequency of metastases and stage IV disease compared to the non-functional ones (p < 0.05). The overall survival of patients with functional tumors was 104 ± 56.72 months, but it was not significantly longer compared to non-functional ones (p = 0.259). However, a difference in survival existed between subgroups of functional tumors depending on hormone secretion (p < 0.05), where insulinomas showed the longest survival and the shortest survival was among patients with ectopic ACTH/CRH production. Conclusion: There were no differences in survival between functional and non-functional tumors overall, but we demonstrated that some tumors' hormonal products represent a good survival marker, such as in insulinomas, while the ectopic secretion of the ACTH/CRH represents a marker of poor survival. |
| format | Article |
| id | doaj-art-7e4ff678824c4738b25868798c6368ea |
| institution | OA Journals |
| issn | 0369-1527 2466-5525 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | University of Belgrade, Medical Faculty |
| record_format | Article |
| series | Medicinski Podmladak |
| spelling | doaj-art-7e4ff678824c4738b25868798c6368ea2025-08-20T01:50:02ZengUniversity of Belgrade, Medical FacultyMedicinski Podmladak0369-15272466-55252024-01-01756545910.5937/mp75-532540369-15272406054MIncidence, clinical features and survival among patients with functional pancreatic neuroendrocrine tumorsMijušković Ana0Čamur Viktor1Popović Bojana2Univerzitet u Beogradu, Medicinski fakultet, Beograd, SerbiaUniverzitet u Beogradu, Medicinski fakultet, Beograd, SerbiaUniverzitet u Beogradu, Medicinski fakultet, Beograd, SerbiaIntroduction: Neuroendocrine tumors (NET) are rare neoplasms derived from neuroendocrine cells that have the ability to synthesize biogenic amines and peptide hormones. Lungs, small and large intestine and pancreas are the most common localizations of these tumors. Depending on the existence of the hormone secretory syndrome and its clinical manifestations, NETs are divided into functional and non-functional tumors. Aim: The aim of this study was to investigate the incidence, biological behavior and survival of patients with functional pancreatic neuroendocrine tumors. Material and methods: We analyzed 272 patients diagnosed with pancreatic NET. Tumor grade was evaluated based on pathohistological characteristics of the tissue samples obtained by biopsy or surgery, while stage was determined based on the size of the primary tumor and the presence of locoregional and/or distant dissemination. Diagnoses were established by using indicative clinical presentations and by determining baseline hormone values, appropriate functional testing and immunohistochemical confirmation of the secretory product in the tumor tissue sample. Results: Among 272 retrospectively analyzed patients, 77.6% of patients had non-functional tumors, while functional tumors were found in 22.4% cases. Functional NETs were significantly smaller and had a lower tumor grade, as well as significantly lower frequency of metastases and stage IV disease compared to the non-functional ones (p < 0.05). The overall survival of patients with functional tumors was 104 ± 56.72 months, but it was not significantly longer compared to non-functional ones (p = 0.259). However, a difference in survival existed between subgroups of functional tumors depending on hormone secretion (p < 0.05), where insulinomas showed the longest survival and the shortest survival was among patients with ectopic ACTH/CRH production. Conclusion: There were no differences in survival between functional and non-functional tumors overall, but we demonstrated that some tumors' hormonal products represent a good survival marker, such as in insulinomas, while the ectopic secretion of the ACTH/CRH represents a marker of poor survival.https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2024/0369-15272406054M.pdfpancreatic neuroendocrine tumorsfunctional tumorshormone syndromesurvival |
| spellingShingle | Mijušković Ana Čamur Viktor Popović Bojana Incidence, clinical features and survival among patients with functional pancreatic neuroendrocrine tumors Medicinski Podmladak pancreatic neuroendocrine tumors functional tumors hormone syndrome survival |
| title | Incidence, clinical features and survival among patients with functional pancreatic neuroendrocrine tumors |
| title_full | Incidence, clinical features and survival among patients with functional pancreatic neuroendrocrine tumors |
| title_fullStr | Incidence, clinical features and survival among patients with functional pancreatic neuroendrocrine tumors |
| title_full_unstemmed | Incidence, clinical features and survival among patients with functional pancreatic neuroendrocrine tumors |
| title_short | Incidence, clinical features and survival among patients with functional pancreatic neuroendrocrine tumors |
| title_sort | incidence clinical features and survival among patients with functional pancreatic neuroendrocrine tumors |
| topic | pancreatic neuroendocrine tumors functional tumors hormone syndrome survival |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2024/0369-15272406054M.pdf |
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