The Parasite-Derived Peptide, FhHDM-1, Selectively Modulates miRNA Expression in β-Cells to Prevent Apoptotic Pathways Induced by Proinflammatory Cytokines

The Parasite-Derived Peptide, FhHDM-1, Selectively Modulates miRNA Expression in β-Cells to Prevent Apoptotic Pathways Induced by Proinflammatory Cytokines

We have previously identified a parasite-derived peptide, FhHDM-1, that prevented the progression of diabetes in nonobese diabetic (NOD) mice. Disease prevention was mediated by the activation of the PI3K/Akt pathway to promote β-cell survival and metabolism without inducing proliferation. To determ...

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Bibliographic Details
Main Authors: Inah Camaya, Meredith Hill, Dayna Sais, Nham Tran, Bronwyn O’Brien, Sheila Donnelly
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2024/8555211
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