Bovine and goat milk fat globule membrane supplementation alleviates autism-like behavior by modulating lipid metabolism and gut microbiota
Autism spectrum disorder (ASD) is a neurodevelopmental disorder influenced by genes and the environment. This study investigated the protective effects of bovine milk fat globule membrane (BMFGM) and goat milk fat globule membrane (GMFGM) supplementation on ASD model mice. Analysis of phospholipid c...
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Tsinghua University Press
2025-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2024.9250159 |
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| author | Rui Guo Xiao Xiao Chuanchuan Wang Tian Yuan Qianhui Zou Tian Zhang Jiarui Liang Ying He Zhuo Liu Xuebo Liu Shan Wu Zhigang Liu |
| author_facet | Rui Guo Xiao Xiao Chuanchuan Wang Tian Yuan Qianhui Zou Tian Zhang Jiarui Liang Ying He Zhuo Liu Xuebo Liu Shan Wu Zhigang Liu |
| author_sort | Rui Guo |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is a neurodevelopmental disorder influenced by genes and the environment. This study investigated the protective effects of bovine milk fat globule membrane (BMFGM) and goat milk fat globule membrane (GMFGM) supplementation on ASD model mice. Analysis of phospholipid composition showed higher levels of phosphatidylcholine in BMFGM and phosphatidylethanolamine in GMFGM. Behavioral results indicated MFGMs ameliorated social deficits, with GMFGM being more effective. Milk fat globule membrane (MFGM) mitigated neuroinflammation by suppressing microglial overactivation and proinflammatory cytokines expression, meanwhile GMFGM increased the anti-inflammatory factor interleukin (IL)-10. MFGMs also altered gut microbiota composition and maintained gut barrier integrity. Uniquely, GMFGM increased butyrate production. Correlation analysis revealed positive associations between social behavior, levels of phosphatidylcholine, sphingomyelin, and the abundance of Allobaculum, Clostridium_sensu_stricto, and Turicibacter. Overall, these findings revealed the protective effects of MFGMs on neurodevelopment in ASD animal models and the underlying mechanism could be partly explained by their regulation of gut microbiota by the phospholipid components in MFGM. |
| format | Article |
| id | doaj-art-7e4c22604ff8403ab351f1d31c8bd426 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-7e4c22604ff8403ab351f1d31c8bd4262025-08-20T03:59:44ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302025-07-01147925015910.26599/FSHW.2024.9250159Bovine and goat milk fat globule membrane supplementation alleviates autism-like behavior by modulating lipid metabolism and gut microbiotaRui Guo0Xiao Xiao1Chuanchuan Wang2Tian Yuan3Qianhui Zou4Tian Zhang5Jiarui Liang6Ying He7Zhuo Liu8Xuebo Liu9Shan Wu10Zhigang Liu11Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaNorthwest A&F University Shenzhen Research Institute, Shenzhen 518000, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaResearch and Development Center, Xi’an Yinqiao Dairy (Group) Co., Ltd., Xi’an 710075, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaResearch and Development Center, Xi’an Yinqiao Dairy (Group) Co., Ltd., Xi’an 710075, ChinaLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaAutism spectrum disorder (ASD) is a neurodevelopmental disorder influenced by genes and the environment. This study investigated the protective effects of bovine milk fat globule membrane (BMFGM) and goat milk fat globule membrane (GMFGM) supplementation on ASD model mice. Analysis of phospholipid composition showed higher levels of phosphatidylcholine in BMFGM and phosphatidylethanolamine in GMFGM. Behavioral results indicated MFGMs ameliorated social deficits, with GMFGM being more effective. Milk fat globule membrane (MFGM) mitigated neuroinflammation by suppressing microglial overactivation and proinflammatory cytokines expression, meanwhile GMFGM increased the anti-inflammatory factor interleukin (IL)-10. MFGMs also altered gut microbiota composition and maintained gut barrier integrity. Uniquely, GMFGM increased butyrate production. Correlation analysis revealed positive associations between social behavior, levels of phosphatidylcholine, sphingomyelin, and the abundance of Allobaculum, Clostridium_sensu_stricto, and Turicibacter. Overall, these findings revealed the protective effects of MFGMs on neurodevelopment in ASD animal models and the underlying mechanism could be partly explained by their regulation of gut microbiota by the phospholipid components in MFGM.https://www.sciopen.com/article/10.26599/FSHW.2024.9250159autism spectrum disordermilk fat globule membranegut microbiotaphospholipids metabolismbutyrate |
| spellingShingle | Rui Guo Xiao Xiao Chuanchuan Wang Tian Yuan Qianhui Zou Tian Zhang Jiarui Liang Ying He Zhuo Liu Xuebo Liu Shan Wu Zhigang Liu Bovine and goat milk fat globule membrane supplementation alleviates autism-like behavior by modulating lipid metabolism and gut microbiota Food Science and Human Wellness autism spectrum disorder milk fat globule membrane gut microbiota phospholipids metabolism butyrate |
| title | Bovine and goat milk fat globule membrane supplementation alleviates autism-like behavior by modulating lipid metabolism and gut microbiota |
| title_full | Bovine and goat milk fat globule membrane supplementation alleviates autism-like behavior by modulating lipid metabolism and gut microbiota |
| title_fullStr | Bovine and goat milk fat globule membrane supplementation alleviates autism-like behavior by modulating lipid metabolism and gut microbiota |
| title_full_unstemmed | Bovine and goat milk fat globule membrane supplementation alleviates autism-like behavior by modulating lipid metabolism and gut microbiota |
| title_short | Bovine and goat milk fat globule membrane supplementation alleviates autism-like behavior by modulating lipid metabolism and gut microbiota |
| title_sort | bovine and goat milk fat globule membrane supplementation alleviates autism like behavior by modulating lipid metabolism and gut microbiota |
| topic | autism spectrum disorder milk fat globule membrane gut microbiota phospholipids metabolism butyrate |
| url | https://www.sciopen.com/article/10.26599/FSHW.2024.9250159 |
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