Intrauterine Growth Restriction: Effects of Physiological Fetal Growth Determinants on Diagnosis
The growth of the fetus, which is strongly associated with the outcome of pregnancy, reflects interplay of several physiological and pathological factors. The assessment of fetal growth is based on comparison of birthweight (BW) or estimated fetal weight (EFW) to standards which define reference ran...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2013/708126 |
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| author | Kjell Haram Eirik Søfteland Radek Bukowski |
| author_facet | Kjell Haram Eirik Søfteland Radek Bukowski |
| author_sort | Kjell Haram |
| collection | DOAJ |
| description | The growth of the fetus, which is strongly associated with the outcome of pregnancy, reflects interplay of several physiological and pathological factors. The assessment of fetal growth is based on comparison of birthweight (BW) or estimated fetal weight (EFW) to standards which define reference ranges at a spectrum of gestational ages. Most birthweight standards do not take into account effects of physiological determinants of fetal growth. Additionally, gestational age in many standards is based on the menstrual history and is often inaccurate. Fetal growth norms should be based on an early ultrasound estimate of gestational age. Customized standards, which have included only ultrasound-dated pregnancies, seem to be superior to population-based birthweight norms in predicting perinatal mortality and morbidity. Adjustment for individual variation in customized growth curves reduces false-positive diagnosis of IUGR and may lead to a very significant reduction in intervention for suspected IUGR. Customized growth potential identifies better the risk for adverse outcome than the currently used national standards, but customized charts may fail in detecting growth-restricted stillbirth. An individual’s birthweight is the sum of physiological and pathological influences operating during pregnancy. Growth potential norms are a better discriminator of aberrations of fetal growth than population, ultrasound, and customized norms. |
| format | Article |
| id | doaj-art-7e4c1f6c980a493b8b183df1877a1ad6 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-7e4c1f6c980a493b8b183df1877a1ad62025-02-03T01:01:57ZengWileyObstetrics and Gynecology International1687-95891687-95972013-01-01201310.1155/2013/708126708126Intrauterine Growth Restriction: Effects of Physiological Fetal Growth Determinants on DiagnosisKjell Haram0Eirik Søfteland1Radek Bukowski2Department of Obstetrics and Gynecology, Haukeland University Hospital, 5021 Bergen, NorwayDepartment of Anesthesia and Intensive Care, Haukeland University Hospital, 5021 Bergen, NorwayDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USAThe growth of the fetus, which is strongly associated with the outcome of pregnancy, reflects interplay of several physiological and pathological factors. The assessment of fetal growth is based on comparison of birthweight (BW) or estimated fetal weight (EFW) to standards which define reference ranges at a spectrum of gestational ages. Most birthweight standards do not take into account effects of physiological determinants of fetal growth. Additionally, gestational age in many standards is based on the menstrual history and is often inaccurate. Fetal growth norms should be based on an early ultrasound estimate of gestational age. Customized standards, which have included only ultrasound-dated pregnancies, seem to be superior to population-based birthweight norms in predicting perinatal mortality and morbidity. Adjustment for individual variation in customized growth curves reduces false-positive diagnosis of IUGR and may lead to a very significant reduction in intervention for suspected IUGR. Customized growth potential identifies better the risk for adverse outcome than the currently used national standards, but customized charts may fail in detecting growth-restricted stillbirth. An individual’s birthweight is the sum of physiological and pathological influences operating during pregnancy. Growth potential norms are a better discriminator of aberrations of fetal growth than population, ultrasound, and customized norms.http://dx.doi.org/10.1155/2013/708126 |
| spellingShingle | Kjell Haram Eirik Søfteland Radek Bukowski Intrauterine Growth Restriction: Effects of Physiological Fetal Growth Determinants on Diagnosis Obstetrics and Gynecology International |
| title | Intrauterine Growth Restriction: Effects of Physiological Fetal Growth Determinants on Diagnosis |
| title_full | Intrauterine Growth Restriction: Effects of Physiological Fetal Growth Determinants on Diagnosis |
| title_fullStr | Intrauterine Growth Restriction: Effects of Physiological Fetal Growth Determinants on Diagnosis |
| title_full_unstemmed | Intrauterine Growth Restriction: Effects of Physiological Fetal Growth Determinants on Diagnosis |
| title_short | Intrauterine Growth Restriction: Effects of Physiological Fetal Growth Determinants on Diagnosis |
| title_sort | intrauterine growth restriction effects of physiological fetal growth determinants on diagnosis |
| url | http://dx.doi.org/10.1155/2013/708126 |
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