Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristics
IntroductionDepressive/anxiety symptoms are common in subjective cognitive decline (SCD) and may relate to Alzheimer’s pathology, potentially modulated by personality characteristics.MethodsDepressive/anxiety symptoms were assessed over 4 ± 2 years in 329 SCD (88 amyloid-positive/241 amyloid-negativ...
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2025-06-01
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| author | Calvin Trieu Calvin Trieu Calvin Trieu Mardou S. S. A. van Leeuwenstijn Mardou S. S. A. van Leeuwenstijn Lisa-Marie Schlüter Lisa-Marie Schlüter Jarith L. Ebenau Jarith L. Ebenau Inge M. W. Verberk Inge M. W. Verberk Sietske A. M. Sikkes Sietske A. M. Sikkes Sietske A. M. Sikkes Sander C. J. Verfaillie Sander C. J. Verfaillie Sander C. J. Verfaillie Elsmarieke van de Giessen Charlotte E. Teunissen Wiesje M. van der Flier Wiesje M. van der Flier Argonde C. van Harten Argonde C. van Harten |
| author_facet | Calvin Trieu Calvin Trieu Calvin Trieu Mardou S. S. A. van Leeuwenstijn Mardou S. S. A. van Leeuwenstijn Lisa-Marie Schlüter Lisa-Marie Schlüter Jarith L. Ebenau Jarith L. Ebenau Inge M. W. Verberk Inge M. W. Verberk Sietske A. M. Sikkes Sietske A. M. Sikkes Sietske A. M. Sikkes Sander C. J. Verfaillie Sander C. J. Verfaillie Sander C. J. Verfaillie Elsmarieke van de Giessen Charlotte E. Teunissen Wiesje M. van der Flier Wiesje M. van der Flier Argonde C. van Harten Argonde C. van Harten |
| author_sort | Calvin Trieu |
| collection | DOAJ |
| description | IntroductionDepressive/anxiety symptoms are common in subjective cognitive decline (SCD) and may relate to Alzheimer’s pathology, potentially modulated by personality characteristics.MethodsDepressive/anxiety symptoms were assessed over 4 ± 2 years in 329 SCD (88 amyloid-positive/241 amyloid-negative) using Geriatric Depression Scale-15 (GDS), Center for Epidemiological Studies-Depression (CES-D), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Mixed-effects models assessed associations between amyloid status and these symptoms, with neuroticism and somatization as effect-modifiers.ResultsAmyloid status was not directly associated with GDS, CES-D or HADS-A. However, neuroticism modified the association between amyloid status and GDS (p<0.05). In lower neuroticism, amyloid positivity was associated with GDS increase (β:0.10 ± 0.08), but not in higher neuroticism (β:-0.04 ± 0.12). Somatization modified the association between amyloid status and CES-D (p<0.05). In lower somatization, amyloid positivity was associated with CES-D increase (β:0.65 ± 0.23), but not in higher somatization (β:-0.12 ± 0.29).DiscussionAmyloid-positive individuals with lower neuroticism/somatization increased more in depressive symptoms over time, suggesting a preclinical AD-related depressive phenotype. |
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| publishDate | 2025-06-01 |
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| spelling | doaj-art-7e4a1b515d2b475e864dfa2e85fffa572025-08-20T02:35:32ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-06-011610.3389/fpsyt.2025.15721741572174Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristicsCalvin Trieu0Calvin Trieu1Calvin Trieu2Mardou S. S. A. van Leeuwenstijn3Mardou S. S. A. van Leeuwenstijn4Lisa-Marie Schlüter5Lisa-Marie Schlüter6Jarith L. Ebenau7Jarith L. Ebenau8Inge M. W. Verberk9Inge M. W. Verberk10Sietske A. M. Sikkes11Sietske A. M. Sikkes12Sietske A. M. Sikkes13Sander C. J. Verfaillie14Sander C. J. Verfaillie15Sander C. J. Verfaillie16Elsmarieke van de Giessen17Charlotte E. Teunissen18Wiesje M. van der Flier19Wiesje M. van der Flier20Argonde C. van Harten21Argonde C. van Harten22Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center (UMC) location Vrije Universiteit Medical Center (VUmc), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsAmsterdam Neuroscience, Neurodegeneration, Amsterdam, NetherlandsNeurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Program Neurodegeneration, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsAlzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center (UMC) location Vrije Universiteit Medical Center (VUmc), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsAmsterdam Neuroscience, Neurodegeneration, Amsterdam, NetherlandsAlzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center (UMC) location Vrije Universiteit Medical Center (VUmc), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsAmsterdam Neuroscience, Neurodegeneration, Amsterdam, NetherlandsAlzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center (UMC) location Vrije Universiteit Medical Center (VUmc), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsAmsterdam Neuroscience, Neurodegeneration, Amsterdam, NetherlandsAlzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center (UMC) location Vrije Universiteit Medical Center (VUmc), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsNeurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Program Neurodegeneration, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsAlzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center (UMC) location Vrije Universiteit Medical Center (VUmc), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsAmsterdam Neuroscience, Neurodegeneration, Amsterdam, NetherlandsFaculty of Behavioural and Movement Sciences, Clinical Developmental Psychology & Clinical Neuropsychology, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDepartment of Radiology & Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam University Medical Center (UMC), Amsterdam, NetherlandsDepartment of Medical Psychology, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam University Medical Center (UMC), Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam University Medical Center (UMC) location Universiteit Medical Center (VUmc), Amsterdam, NetherlandsDepartment of Radiology & Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam University Medical Center (UMC), Amsterdam, NetherlandsNeurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Program Neurodegeneration, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsAlzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center (UMC) location Vrije Universiteit Medical Center (VUmc), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsAmsterdam Neuroscience, Neurodegeneration, Amsterdam, NetherlandsAlzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center (UMC) location Vrije Universiteit Medical Center (VUmc), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsAmsterdam Neuroscience, Neurodegeneration, Amsterdam, NetherlandsIntroductionDepressive/anxiety symptoms are common in subjective cognitive decline (SCD) and may relate to Alzheimer’s pathology, potentially modulated by personality characteristics.MethodsDepressive/anxiety symptoms were assessed over 4 ± 2 years in 329 SCD (88 amyloid-positive/241 amyloid-negative) using Geriatric Depression Scale-15 (GDS), Center for Epidemiological Studies-Depression (CES-D), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Mixed-effects models assessed associations between amyloid status and these symptoms, with neuroticism and somatization as effect-modifiers.ResultsAmyloid status was not directly associated with GDS, CES-D or HADS-A. However, neuroticism modified the association between amyloid status and GDS (p<0.05). In lower neuroticism, amyloid positivity was associated with GDS increase (β:0.10 ± 0.08), but not in higher neuroticism (β:-0.04 ± 0.12). Somatization modified the association between amyloid status and CES-D (p<0.05). In lower somatization, amyloid positivity was associated with CES-D increase (β:0.65 ± 0.23), but not in higher somatization (β:-0.12 ± 0.29).DiscussionAmyloid-positive individuals with lower neuroticism/somatization increased more in depressive symptoms over time, suggesting a preclinical AD-related depressive phenotype.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1572174/fullAlzheimer’s diseasedepressionanxietysubjective cognitive declineneuroticismsomatization |
| spellingShingle | Calvin Trieu Calvin Trieu Calvin Trieu Mardou S. S. A. van Leeuwenstijn Mardou S. S. A. van Leeuwenstijn Lisa-Marie Schlüter Lisa-Marie Schlüter Jarith L. Ebenau Jarith L. Ebenau Inge M. W. Verberk Inge M. W. Verberk Sietske A. M. Sikkes Sietske A. M. Sikkes Sietske A. M. Sikkes Sander C. J. Verfaillie Sander C. J. Verfaillie Sander C. J. Verfaillie Elsmarieke van de Giessen Charlotte E. Teunissen Wiesje M. van der Flier Wiesje M. van der Flier Argonde C. van Harten Argonde C. van Harten Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristics Frontiers in Psychiatry Alzheimer’s disease depression anxiety subjective cognitive decline neuroticism somatization |
| title | Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristics |
| title_full | Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristics |
| title_fullStr | Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristics |
| title_full_unstemmed | Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristics |
| title_short | Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristics |
| title_sort | longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline the impact of personality characteristics |
| topic | Alzheimer’s disease depression anxiety subjective cognitive decline neuroticism somatization |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1572174/full |
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