Cholesterol affects the binding of proteins to phosphatidic acid without influencing its ionization properties

Cholesterol affects the binding of proteins to phosphatidic acid without influencing its ionization properties

Phosphatidic acid (PA) through its unique negatively charged phosphate headgroup binds to various proteins to modulate multiple cellular events. To perform such diverse signaling functions, the ionization and charge of PA's headgroup rely on the properties of vicinal membrane lipids and changes...

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Bibliographic Details
Main Authors: Desmond Owusu Kwarteng, Alexander Wolf, Madisyn Langdon, Nawal Kassas, Nicolas Vitale, Edgar Eduard Kooijman
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Journal of Lipid Research
Subjects:
cholesterol
phosphatidic acid
lipid-protein interactions
Signaling lipids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000094
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