MULTIOMICS INTEGRATION IN ANTI-TUBERCULOSIS DRUG DISCOVERY
Despite intensive global efforts, tuberculosis remains one of the leading global health burdens, with antimicrobial resistance being a significant challenge to managing the disease. In addition, the current drugs used to treat tuberculosis suffer from limitations, such as prolonged therapeutic durat...
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| Format: | Article |
| Language: | English |
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Association of medical doctors Sanamed Novi Pazar
2025-05-01
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| Series: | Sanamed |
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| Online Access: | https://new.sanamed.rs/pdf/20_1/20_1_11.pdf |
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| _version_ | 1849329400188764160 |
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| author | Yaro Abubakar |
| author_facet | Yaro Abubakar |
| author_sort | Yaro Abubakar |
| collection | DOAJ |
| description | Despite intensive global efforts, tuberculosis remains one of the leading global health burdens, with antimicrobial resistance being a significant challenge to managing the disease. In addition, the current drugs used to treat tuberculosis suffer from limitations, such as prolonged therapeutic duration and toxicity. Therefore, the development of new anti-tuberculosis drugs is a priority. However, this process faces several challenges. The introduction of a multiomics approach could serve as an ideal platform to accelerate drug development by addressing these challenges. This article reviews the potential role of multiomics in anti-tuberculosis drug development and briefly discusses the associated challenges in utilizing multiomics for drug discovery. |
| format | Article |
| id | doaj-art-7e45d886d7c14cb89b93a4d93576e470 |
| institution | Kabale University |
| issn | 1452-662X 2217-8171 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Association of medical doctors Sanamed Novi Pazar |
| record_format | Article |
| series | Sanamed |
| spelling | doaj-art-7e45d886d7c14cb89b93a4d93576e4702025-08-20T03:47:16ZengAssociation of medical doctors Sanamed Novi PazarSanamed1452-662X2217-81712025-05-01201899610.5937/sanamed0-51644MULTIOMICS INTEGRATION IN ANTI-TUBERCULOSIS DRUG DISCOVERYYaro Abubakar0https://orcid.org/0000-0002-0524-13941. AHRO Center for Academic Research, Basic and Clinical Research Department, London, United Kingdom; 2. Research Fellow, Birkbeck College, London, United Kingdom; 3. Africa Health Research Organization, Accra, GhanaDespite intensive global efforts, tuberculosis remains one of the leading global health burdens, with antimicrobial resistance being a significant challenge to managing the disease. In addition, the current drugs used to treat tuberculosis suffer from limitations, such as prolonged therapeutic duration and toxicity. Therefore, the development of new anti-tuberculosis drugs is a priority. However, this process faces several challenges. The introduction of a multiomics approach could serve as an ideal platform to accelerate drug development by addressing these challenges. This article reviews the potential role of multiomics in anti-tuberculosis drug development and briefly discusses the associated challenges in utilizing multiomics for drug discovery.https://new.sanamed.rs/pdf/20_1/20_1_11.pdftuberculosisdrugsproteomicsmultiomicsmycobacterium tuberculosistranscriptomicsmetabolomicsgenomics |
| spellingShingle | Yaro Abubakar MULTIOMICS INTEGRATION IN ANTI-TUBERCULOSIS DRUG DISCOVERY Sanamed tuberculosis drugs proteomics multiomics mycobacterium tuberculosis transcriptomics metabolomics genomics |
| title | MULTIOMICS INTEGRATION IN ANTI-TUBERCULOSIS DRUG DISCOVERY |
| title_full | MULTIOMICS INTEGRATION IN ANTI-TUBERCULOSIS DRUG DISCOVERY |
| title_fullStr | MULTIOMICS INTEGRATION IN ANTI-TUBERCULOSIS DRUG DISCOVERY |
| title_full_unstemmed | MULTIOMICS INTEGRATION IN ANTI-TUBERCULOSIS DRUG DISCOVERY |
| title_short | MULTIOMICS INTEGRATION IN ANTI-TUBERCULOSIS DRUG DISCOVERY |
| title_sort | multiomics integration in anti tuberculosis drug discovery |
| topic | tuberculosis drugs proteomics multiomics mycobacterium tuberculosis transcriptomics metabolomics genomics |
| url | https://new.sanamed.rs/pdf/20_1/20_1_11.pdf |
| work_keys_str_mv | AT yaroabubakar multiomicsintegrationinantituberculosisdrugdiscovery |