Epigenetic modulation of the NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infection

Epigenetic modulation of the NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infection

Abstract Background Gastrointestinal (GI) disease/dysfunction persists in people living with HIV (PLWH) receiving suppressive combination anti-retroviral therapy (ART) leading to epithelial barrier breakdown, microbial translocation and systemic inflammation that can drive non-AIDS associated comorb...

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Bibliographic Details
Main Authors: Lakmini S. Premadasa, Marina McDew-White, Luis Romero, Beverly Gondo, Jade A. Drawec, Binhua Ling, Chioma M. Okeoma, Mahesh Mohan
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell Communication and Signaling
Online Access:https://doi.org/10.1186/s12964-025-02193-0
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