Deletion of Chromosome 4q Predicts Outcome in Stage II Colon Cancer Patients
Background: Around 30% of all stage II colon cancer patients will relapse and die of their disease. At present no objective parameters to identify high-risk stage II colon cancer patients, who will benefit from adjuvant chemotherapy, have been established. With traditional histopathological features...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.3233/ACP-CLO-2010-0531 |
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| author | R. P. M. Brosens E. J. T. H. Belt J. C. Haan T. E. Buffart B. Carvalho H. Grabsch P. Quirke M. A. Cuesta A. F. Engel B. Ylstra G. A. Meijer |
| author_facet | R. P. M. Brosens E. J. T. H. Belt J. C. Haan T. E. Buffart B. Carvalho H. Grabsch P. Quirke M. A. Cuesta A. F. Engel B. Ylstra G. A. Meijer |
| author_sort | R. P. M. Brosens |
| collection | DOAJ |
| description | Background: Around 30% of all stage II colon cancer patients will relapse and die of their disease. At present no objective parameters to identify high-risk stage II colon cancer patients, who will benefit from adjuvant chemotherapy, have been established. With traditional histopathological features definition of high-risk stage II colon cancer patients is inaccurate. Therefore more objective and robust markers for prediction of relapse are needed. DNA copy number aberrations have proven to be robust prognostic markers, but have not yet been investigated for this specific group of patients. The aim of the present study was to identify chromosomal aberrations that can predict relapse of tumor in patients with stage II colon cancer. |
| format | Article |
| id | doaj-art-7e407eabe0f643e48895b844d8e4eebb |
| institution | OA Journals |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-7e407eabe0f643e48895b844d8e4eebb2025-08-20T02:08:57ZengWileyAnalytical Cellular Pathology2210-71772210-71852010-01-013329510410.3233/ACP-CLO-2010-0531Deletion of Chromosome 4q Predicts Outcome in Stage II Colon Cancer PatientsR. P. M. Brosens0E. J. T. H. Belt1J. C. Haan2T. E. Buffart3B. Carvalho4H. Grabsch5P. Quirke6M. A. Cuesta7A. F. Engel8B. Ylstra9G. A. Meijer10Department of Surgery, VU University Medical Centre, Amsterdam, The NetherlandsDepartment of Surgery, VU University Medical Centre, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Centre, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Centre, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Centre, Amsterdam, The NetherlandsPathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UKPathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UKDepartment of Surgery, VU University Medical Centre, Amsterdam, The NetherlandsDepartment of Surgery, Zaans Medical Centre, Zaandam, The NetherlandsDepartment of Pathology, VU University Medical Centre, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Centre, Amsterdam, The NetherlandsBackground: Around 30% of all stage II colon cancer patients will relapse and die of their disease. At present no objective parameters to identify high-risk stage II colon cancer patients, who will benefit from adjuvant chemotherapy, have been established. With traditional histopathological features definition of high-risk stage II colon cancer patients is inaccurate. Therefore more objective and robust markers for prediction of relapse are needed. DNA copy number aberrations have proven to be robust prognostic markers, but have not yet been investigated for this specific group of patients. The aim of the present study was to identify chromosomal aberrations that can predict relapse of tumor in patients with stage II colon cancer.http://dx.doi.org/10.3233/ACP-CLO-2010-0531 |
| spellingShingle | R. P. M. Brosens E. J. T. H. Belt J. C. Haan T. E. Buffart B. Carvalho H. Grabsch P. Quirke M. A. Cuesta A. F. Engel B. Ylstra G. A. Meijer Deletion of Chromosome 4q Predicts Outcome in Stage II Colon Cancer Patients Analytical Cellular Pathology |
| title | Deletion of Chromosome 4q Predicts Outcome in Stage II Colon Cancer Patients |
| title_full | Deletion of Chromosome 4q Predicts Outcome in Stage II Colon Cancer Patients |
| title_fullStr | Deletion of Chromosome 4q Predicts Outcome in Stage II Colon Cancer Patients |
| title_full_unstemmed | Deletion of Chromosome 4q Predicts Outcome in Stage II Colon Cancer Patients |
| title_short | Deletion of Chromosome 4q Predicts Outcome in Stage II Colon Cancer Patients |
| title_sort | deletion of chromosome 4q predicts outcome in stage ii colon cancer patients |
| url | http://dx.doi.org/10.3233/ACP-CLO-2010-0531 |
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