Techniques and graft materials for repairing peripheral nerve defects
Peripheral nerve defects refer to damage or destruction occurring in the peripheral nervous system, typically affecting the limbs and face. The current primary approaches to address peripheral nerve defects involve the utilization of autologous nerve transplants or the transplantation of artificial...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1307883/full |
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| author | Xiaodi Zou Xiaodi Zou Yanzhao Dong Ahmad Alhaskawi Haiying Zhou Sohaib Hasan Abdullah Ezzi Vishnu Goutham Kota Mohamed Hasan Abdulla Hasan Abdulla Sahar Ahmed Abdalbary Hui Lu Hui Lu Changxin Wang |
| author_facet | Xiaodi Zou Xiaodi Zou Yanzhao Dong Ahmad Alhaskawi Haiying Zhou Sohaib Hasan Abdullah Ezzi Vishnu Goutham Kota Mohamed Hasan Abdulla Hasan Abdulla Sahar Ahmed Abdalbary Hui Lu Hui Lu Changxin Wang |
| author_sort | Xiaodi Zou |
| collection | DOAJ |
| description | Peripheral nerve defects refer to damage or destruction occurring in the peripheral nervous system, typically affecting the limbs and face. The current primary approaches to address peripheral nerve defects involve the utilization of autologous nerve transplants or the transplantation of artificial material. Nevertheless, these methods possess certain limitations, such as inadequate availability of donor nerve or unsatisfactory regenerative outcomes post-transplantation. Biomaterials have been extensively studied as an alternative approach to promote the repair of peripheral neve defects. These biomaterials include both natural and synthetic materials. Natural materials consist of collagen, chitosan, and silk, while synthetic materials consist of polyurethane, polylactic acid, and polycaprolactone. Recently, several new neural repair technologies have also been developed, such as nerve regeneration bridging technology, electrical stimulation technology, and stem cell therapy technology. Overall, biomaterials and new neural repair technologies provide new methods and opportunities for repairing peripheral nerve defects. However, these methods still require further research and development to enhance their effectiveness and feasibility. |
| format | Article |
| id | doaj-art-7e3d5dc698b742c793fa9c6a231c0b21 |
| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-7e3d5dc698b742c793fa9c6a231c0b212025-08-20T02:36:30ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-01-011410.3389/fneur.2023.13078831307883Techniques and graft materials for repairing peripheral nerve defectsXiaodi Zou0Xiaodi Zou1Yanzhao Dong2Ahmad Alhaskawi3Haiying Zhou4Sohaib Hasan Abdullah Ezzi5Vishnu Goutham Kota6Mohamed Hasan Abdulla Hasan Abdulla7Sahar Ahmed Abdalbary8Hui Lu9Hui Lu10Changxin Wang11Department of Orthopedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedics, Third Xiangya Hospital, Central South University, Changsha, ChinaZhejiang University School of Medicine, Hangzhou, ChinaZhejiang University School of Medicine, Hangzhou, ChinaDepartment of Orthopedic Physical Therapy, Faculty of Physical Therapy, Nahda University in Beni Suef, Beni Suef, EgyptDepartment of Orthopedics, The First Affiliated Hospital, Zhejiang University, Hangzhou, ChinaAlibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaPeripheral nerve defects refer to damage or destruction occurring in the peripheral nervous system, typically affecting the limbs and face. The current primary approaches to address peripheral nerve defects involve the utilization of autologous nerve transplants or the transplantation of artificial material. Nevertheless, these methods possess certain limitations, such as inadequate availability of donor nerve or unsatisfactory regenerative outcomes post-transplantation. Biomaterials have been extensively studied as an alternative approach to promote the repair of peripheral neve defects. These biomaterials include both natural and synthetic materials. Natural materials consist of collagen, chitosan, and silk, while synthetic materials consist of polyurethane, polylactic acid, and polycaprolactone. Recently, several new neural repair technologies have also been developed, such as nerve regeneration bridging technology, electrical stimulation technology, and stem cell therapy technology. Overall, biomaterials and new neural repair technologies provide new methods and opportunities for repairing peripheral nerve defects. However, these methods still require further research and development to enhance their effectiveness and feasibility.https://www.frontiersin.org/articles/10.3389/fneur.2023.1307883/fullperipheral nerve injuriesgraft materialsperipheral nerve defectsnerve regenerationnerve gap |
| spellingShingle | Xiaodi Zou Xiaodi Zou Yanzhao Dong Ahmad Alhaskawi Haiying Zhou Sohaib Hasan Abdullah Ezzi Vishnu Goutham Kota Mohamed Hasan Abdulla Hasan Abdulla Sahar Ahmed Abdalbary Hui Lu Hui Lu Changxin Wang Techniques and graft materials for repairing peripheral nerve defects Frontiers in Neurology peripheral nerve injuries graft materials peripheral nerve defects nerve regeneration nerve gap |
| title | Techniques and graft materials for repairing peripheral nerve defects |
| title_full | Techniques and graft materials for repairing peripheral nerve defects |
| title_fullStr | Techniques and graft materials for repairing peripheral nerve defects |
| title_full_unstemmed | Techniques and graft materials for repairing peripheral nerve defects |
| title_short | Techniques and graft materials for repairing peripheral nerve defects |
| title_sort | techniques and graft materials for repairing peripheral nerve defects |
| topic | peripheral nerve injuries graft materials peripheral nerve defects nerve regeneration nerve gap |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1307883/full |
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