Extracellular vesicles: biological mechanisms and emerging therapeutic opportunities in neurodegenerative diseases
Abstract Extracellular vesicles (EVs) are membrane vesicles originating from different cells within the brain. The pathophysiological role of EVs in neurodegenerative diseases is progressively acknowledged. This field has advanced from basic biological research to essential clinical significance. Th...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Translational Neurodegeneration |
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| Online Access: | https://doi.org/10.1186/s40035-024-00453-6 |
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| _version_ | 1849220578297249792 |
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| author | Ling Wang Xiaoyan Zhang Ziyi Yang Binquan Wang Hongyang Gong Ke Zhang Yi Lin Mingkuan Sun |
| author_facet | Ling Wang Xiaoyan Zhang Ziyi Yang Binquan Wang Hongyang Gong Ke Zhang Yi Lin Mingkuan Sun |
| author_sort | Ling Wang |
| collection | DOAJ |
| description | Abstract Extracellular vesicles (EVs) are membrane vesicles originating from different cells within the brain. The pathophysiological role of EVs in neurodegenerative diseases is progressively acknowledged. This field has advanced from basic biological research to essential clinical significance. The capacity to selectively enrich specific subsets of EVs from biofluids via distinctive surface markers has opened new avenues for molecular understandings across various tissues and organs, notably in the brain. In recent years, brain-derived EVs have been extensively investigated as biomarkers, therapeutic targets, and drug-delivery vehicles for neurodegenerative diseases. This review provides a brief overview of the characteristics and physiological functions of the various classes of EVs, focusing on the biological mechanisms by which various types of brain-derived EVs mediate the occurrence and development of neurodegenerative diseases. Concurrently, novel therapeutic approaches and challenges for the use of EVs as delivery vehicles are delineated. |
| format | Article |
| id | doaj-art-7e3b13457842468cb6b60a5a7ed557ff |
| institution | Kabale University |
| issn | 2047-9158 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Translational Neurodegeneration |
| spelling | doaj-art-7e3b13457842468cb6b60a5a7ed557ff2024-12-08T12:44:20ZengBMCTranslational Neurodegeneration2047-91582024-12-0113112510.1186/s40035-024-00453-6Extracellular vesicles: biological mechanisms and emerging therapeutic opportunities in neurodegenerative diseasesLing Wang0Xiaoyan Zhang1Ziyi Yang2Binquan Wang3Hongyang Gong4Ke Zhang5Yi Lin6Mingkuan Sun7The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical UniversityThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical UniversityThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical UniversityThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical UniversityThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical UniversityThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical UniversityThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical UniversityThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical UniversityAbstract Extracellular vesicles (EVs) are membrane vesicles originating from different cells within the brain. The pathophysiological role of EVs in neurodegenerative diseases is progressively acknowledged. This field has advanced from basic biological research to essential clinical significance. The capacity to selectively enrich specific subsets of EVs from biofluids via distinctive surface markers has opened new avenues for molecular understandings across various tissues and organs, notably in the brain. In recent years, brain-derived EVs have been extensively investigated as biomarkers, therapeutic targets, and drug-delivery vehicles for neurodegenerative diseases. This review provides a brief overview of the characteristics and physiological functions of the various classes of EVs, focusing on the biological mechanisms by which various types of brain-derived EVs mediate the occurrence and development of neurodegenerative diseases. Concurrently, novel therapeutic approaches and challenges for the use of EVs as delivery vehicles are delineated.https://doi.org/10.1186/s40035-024-00453-6Extracellular vesicleNeurodegenerative diseaseBiomarkerTherapeutic strategy |
| spellingShingle | Ling Wang Xiaoyan Zhang Ziyi Yang Binquan Wang Hongyang Gong Ke Zhang Yi Lin Mingkuan Sun Extracellular vesicles: biological mechanisms and emerging therapeutic opportunities in neurodegenerative diseases Translational Neurodegeneration Extracellular vesicle Neurodegenerative disease Biomarker Therapeutic strategy |
| title | Extracellular vesicles: biological mechanisms and emerging therapeutic opportunities in neurodegenerative diseases |
| title_full | Extracellular vesicles: biological mechanisms and emerging therapeutic opportunities in neurodegenerative diseases |
| title_fullStr | Extracellular vesicles: biological mechanisms and emerging therapeutic opportunities in neurodegenerative diseases |
| title_full_unstemmed | Extracellular vesicles: biological mechanisms and emerging therapeutic opportunities in neurodegenerative diseases |
| title_short | Extracellular vesicles: biological mechanisms and emerging therapeutic opportunities in neurodegenerative diseases |
| title_sort | extracellular vesicles biological mechanisms and emerging therapeutic opportunities in neurodegenerative diseases |
| topic | Extracellular vesicle Neurodegenerative disease Biomarker Therapeutic strategy |
| url | https://doi.org/10.1186/s40035-024-00453-6 |
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