Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program
Background: A developing literature suggests that transcranial magnetic stimulation (TMS) can target anhedonia and suicidal ideation (SI), core symptoms of treatment-resistant depression (TRD). This present naturalistic study extends the existing literature by investigating the connection between ch...
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Elsevier
2024-12-01
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| Series: | Journal of Mood and Anxiety Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950004424000270 |
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| author | A. Irem Sonmez Ryan Webler Alyssa M. Krueger Clara Godoy-Henderson Christi Sullivan Saydra Wilson Sarah Olsen Sabine Schmid Alexander Herman Alik Widge Carol Peterson Ziad Nahas C. Sophia Albott |
| author_facet | A. Irem Sonmez Ryan Webler Alyssa M. Krueger Clara Godoy-Henderson Christi Sullivan Saydra Wilson Sarah Olsen Sabine Schmid Alexander Herman Alik Widge Carol Peterson Ziad Nahas C. Sophia Albott |
| author_sort | A. Irem Sonmez |
| collection | DOAJ |
| description | Background: A developing literature suggests that transcranial magnetic stimulation (TMS) can target anhedonia and suicidal ideation (SI), core symptoms of treatment-resistant depression (TRD). This present naturalistic study extends the existing literature by investigating the connection between changes in anhedonia and suicidal ideation (SI) related to transcranial magnetic stimulation (TMS), independent of any overall changes in depression. Methods: Pre and post treatment PHQ-9 and IDS-SR data were collected from 181 TRD patients who received dorsolateral prefrontal cortex ( dlPFC) TMS using the Figure-8 or H1-coil. Changes in overall depression symptoms, anhedonia, and SI were analyzed using chi square tests, repeated measure ANOVAS, and linear regression for repeated measures. Results: TMS yielded changes in overall depression symptoms (PHQ-9 Cohen’s d = 1.02; IDS-SR Cohen’s d = 1.05), with 23.9 % and 41.7 % of patients experiencing response as measured by IDS-SR and PHQ-9, respectively. TMS treatment was also associated with large changes in both anhedonia (d = 1.03) and SI (d = 0.88), which were similar in magnitude to changes in all other depression symptoms (d = 0.97). Importantly, changes in anhedonia predicted changes in SI, even after controlling for baseline depression severity and change in other depression symptoms. Limitations: The lack of a control arm and a neuroimaging measure temper mechanistic conclusion. Conclusion: Our results reinforce the effectiveness of TMS in TRD and provide new evidence that anhedonia and SI may belong to a broader symptom cluster potentially undergirded by a shared circuitry accessible to dlPFC TMS. |
| format | Article |
| id | doaj-art-7e33beb692fa4b6596abbfc4adbf2145 |
| institution | OA Journals |
| issn | 2950-0044 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Mood and Anxiety Disorders |
| spelling | doaj-art-7e33beb692fa4b6596abbfc4adbf21452025-08-20T02:37:49ZengElsevierJournal of Mood and Anxiety Disorders2950-00442024-12-01810007310.1016/j.xjmad.2024.100073Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry ProgramA. Irem Sonmez0Ryan Webler1Alyssa M. Krueger2Clara Godoy-Henderson3Christi Sullivan4Saydra Wilson5Sarah Olsen6Sabine Schmid7Alexander Herman8Alik Widge9Carol Peterson10Ziad Nahas11C. Sophia Albott12Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychology, University of Minnesota, Minneapolis, MN, USA; Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA; Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, MN, USA; Correspondence to: Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, 2450 Riverside Ave., F228, Minneapolis, MN 55454, USA.Background: A developing literature suggests that transcranial magnetic stimulation (TMS) can target anhedonia and suicidal ideation (SI), core symptoms of treatment-resistant depression (TRD). This present naturalistic study extends the existing literature by investigating the connection between changes in anhedonia and suicidal ideation (SI) related to transcranial magnetic stimulation (TMS), independent of any overall changes in depression. Methods: Pre and post treatment PHQ-9 and IDS-SR data were collected from 181 TRD patients who received dorsolateral prefrontal cortex ( dlPFC) TMS using the Figure-8 or H1-coil. Changes in overall depression symptoms, anhedonia, and SI were analyzed using chi square tests, repeated measure ANOVAS, and linear regression for repeated measures. Results: TMS yielded changes in overall depression symptoms (PHQ-9 Cohen’s d = 1.02; IDS-SR Cohen’s d = 1.05), with 23.9 % and 41.7 % of patients experiencing response as measured by IDS-SR and PHQ-9, respectively. TMS treatment was also associated with large changes in both anhedonia (d = 1.03) and SI (d = 0.88), which were similar in magnitude to changes in all other depression symptoms (d = 0.97). Importantly, changes in anhedonia predicted changes in SI, even after controlling for baseline depression severity and change in other depression symptoms. Limitations: The lack of a control arm and a neuroimaging measure temper mechanistic conclusion. Conclusion: Our results reinforce the effectiveness of TMS in TRD and provide new evidence that anhedonia and SI may belong to a broader symptom cluster potentially undergirded by a shared circuitry accessible to dlPFC TMS.http://www.sciencedirect.com/science/article/pii/S2950004424000270Transcranial magnetic stimulation (TMS)Treatment-resistant depression (TRD)AnhedoniaSuicidal ideation |
| spellingShingle | A. Irem Sonmez Ryan Webler Alyssa M. Krueger Clara Godoy-Henderson Christi Sullivan Saydra Wilson Sarah Olsen Sabine Schmid Alexander Herman Alik Widge Carol Peterson Ziad Nahas C. Sophia Albott Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program Journal of Mood and Anxiety Disorders Transcranial magnetic stimulation (TMS) Treatment-resistant depression (TRD) Anhedonia Suicidal ideation |
| title | Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program |
| title_full | Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program |
| title_fullStr | Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program |
| title_full_unstemmed | Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program |
| title_short | Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program |
| title_sort | effects of tms on anhedonia and suicidal ideation in treatment resistant depression outcomes from the university of minnesota interventional psychiatry program |
| topic | Transcranial magnetic stimulation (TMS) Treatment-resistant depression (TRD) Anhedonia Suicidal ideation |
| url | http://www.sciencedirect.com/science/article/pii/S2950004424000270 |
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