Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy
Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. Cancer cells are well known to display an enhanced sugar uptake and consumption. In fact, su...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2010/205357 |
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| _version_ | 1832554095249981440 |
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| author | Moisés Blanco Calvo Angélica Figueroa Enrique Grande Pulido Rosario García Campelo Luís Antón Aparicio |
| author_facet | Moisés Blanco Calvo Angélica Figueroa Enrique Grande Pulido Rosario García Campelo Luís Antón Aparicio |
| author_sort | Moisés Blanco Calvo |
| collection | DOAJ |
| description | Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. Cancer cells are well known to display an enhanced sugar uptake and consumption. In fact, sugar transporters are deregulated in cancer cells so they incorporate higher amounts of sugar than normal cells. In this paper, we compile the most significant data available about biochemical and biological properties of sugar transporters in normal tissues and we review the available information about sugar carrier expression in different types of cancer. Moreover, we describe the possible pharmacological interactions between drugs currently used in anticancer therapy and the expression or function of facilitative sugar transporters. Finally, we also go into the insights about the future design of drugs targeted against sugar utilization in cancer cells. |
| format | Article |
| id | doaj-art-7e2ad95df7cf4d3d9af13e94c621fff3 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-7e2ad95df7cf4d3d9af13e94c621fff32025-02-03T05:52:19ZengWileyInternational Journal of Endocrinology1687-83371687-83452010-01-01201010.1155/2010/205357205357Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer TherapyMoisés Blanco Calvo0Angélica Figueroa1Enrique Grande Pulido2Rosario García Campelo3Luís Antón Aparicio4Biomedical Research Institute, A Coruña University Hospital, As Xubias 84, 15006 A Coruña, SpainBiomedical Research Institute, A Coruña University Hospital, As Xubias 84, 15006 A Coruña, SpainClinical Oncology Department, Ramón y Cajal University Hospital, Ctra. de Colmenar Viejo Km. 9,100, 28034 Madrid, SpainClinical Oncology Department, A Coruña University Hospital, As Xubias 84, 15006 A Coruña, SpainClinical Oncology Department, A Coruña University Hospital, As Xubias 84, 15006 A Coruña, SpainSugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. Cancer cells are well known to display an enhanced sugar uptake and consumption. In fact, sugar transporters are deregulated in cancer cells so they incorporate higher amounts of sugar than normal cells. In this paper, we compile the most significant data available about biochemical and biological properties of sugar transporters in normal tissues and we review the available information about sugar carrier expression in different types of cancer. Moreover, we describe the possible pharmacological interactions between drugs currently used in anticancer therapy and the expression or function of facilitative sugar transporters. Finally, we also go into the insights about the future design of drugs targeted against sugar utilization in cancer cells.http://dx.doi.org/10.1155/2010/205357 |
| spellingShingle | Moisés Blanco Calvo Angélica Figueroa Enrique Grande Pulido Rosario García Campelo Luís Antón Aparicio Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy International Journal of Endocrinology |
| title | Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy |
| title_full | Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy |
| title_fullStr | Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy |
| title_full_unstemmed | Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy |
| title_short | Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy |
| title_sort | potential role of sugar transporters in cancer and their relationship with anticancer therapy |
| url | http://dx.doi.org/10.1155/2010/205357 |
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