Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response

Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response

GATA-3 is a master regulator of preadipocyte differentiation and function. Pharmacological or genetic targeting of GATA-3 will allow us to understand the function of GATA-3 in regulating metabolism, insulin signaling, and inflammation. Pyrrothiogatain, a novel small molecule inhibitor of GATA family...

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Bibliographic Details
Main Authors: Shamma Almuraikhy, Maha Alser, Khaled Naja, Aisha Al-Malki, Nayef A. Mazloum, Mohamed A. Elrayess
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
GATA-3
Pyrrothiogatain
adipogenesis
inflammation
oxidative stress
Online Access:https://www.mdpi.com/2073-4409/14/2/100
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