Topical Administration Effect of Sargassum duplicatum and Garcinia mangostana Extracts Combination on Open Wound Healing Process in Diabetic Mice
This research aimed to determine the topical administration effect of the combination of Sargassum duplicatum and Garcinia mangostana extracts to ameliorate diabetic open wound healing. The study used 24 adult males of Mus musculus (BALB/c strain, 3–4 months, 30–40 g). They were divided into normal...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2022/9700794 |
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| author | Dwi Winarni Fitria Nikmatul Husna Muhammad Farraz Syadzha Raden Joko Kuncoroningrat Susilo Suhailah Hayaza Arif Nur Muhammad Ansori Mochammad Amin Alamsjah Muhamad Nur Ghoyatul Amin Pugar Arga Christina Wulandari Pratiwi Pudjiastuti Khalijah Awang |
| author_facet | Dwi Winarni Fitria Nikmatul Husna Muhammad Farraz Syadzha Raden Joko Kuncoroningrat Susilo Suhailah Hayaza Arif Nur Muhammad Ansori Mochammad Amin Alamsjah Muhamad Nur Ghoyatul Amin Pugar Arga Christina Wulandari Pratiwi Pudjiastuti Khalijah Awang |
| author_sort | Dwi Winarni |
| collection | DOAJ |
| description | This research aimed to determine the topical administration effect of the combination of Sargassum duplicatum and Garcinia mangostana extracts to ameliorate diabetic open wound healing. The study used 24 adult males of Mus musculus (BALB/c strain, 3–4 months, 30–40 g). They were divided into normal control groups (KN) and diabetic groups. The diabetic group was streptozotocin-induced and divided further into three treatment groups: the diabetic control group (KD), the S. duplicatum treatment group (PA), and the combination of S. duplicatum and G. mangostana treatment group (PAM). The dose of treatment was 50 mg/kg of body weight. Each group was divided into three treatment durations, which were 3 days, 7 days, and 14 days. The wound healing process was determined by wound width, the number of neutrophils, macrophages, fibroblasts, fibrocytes, and collagen density. Histological observation showed that the topical administration of combination extracts increased the re-epithelialization of the wounded area, fibroblasts, fibrocytes, and collagen synthesis. The topical administration of combination extracts also decreased the number of neutrophils and macrophages. This study concluded that the topical administration of the combination of S. duplicatum and G. mangostana extracts improved the open wound healing process in diabetic mice. |
| format | Article |
| id | doaj-art-7e23801d5b8e4b3a93760c8bf220e20e |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-7e23801d5b8e4b3a93760c8bf220e20e2025-02-03T05:46:47ZengWileyScientifica2090-908X2022-01-01202210.1155/2022/9700794Topical Administration Effect of Sargassum duplicatum and Garcinia mangostana Extracts Combination on Open Wound Healing Process in Diabetic MiceDwi Winarni0Fitria Nikmatul Husna1Muhammad Farraz Syadzha2Raden Joko Kuncoroningrat Susilo3Suhailah Hayaza4Arif Nur Muhammad Ansori5Mochammad Amin Alamsjah6Muhamad Nur Ghoyatul Amin7Pugar Arga Christina Wulandari8Pratiwi Pudjiastuti9Khalijah Awang10Department of BiologyDepartment of BiologyDepartment of BiologyDepartment of BiologyDepartment of BiologyDepartment of BiologyDepartment of MarineDepartment of MarineDepartment of ChemistryDepartment of ChemistryDepartment of ChemistryThis research aimed to determine the topical administration effect of the combination of Sargassum duplicatum and Garcinia mangostana extracts to ameliorate diabetic open wound healing. The study used 24 adult males of Mus musculus (BALB/c strain, 3–4 months, 30–40 g). They were divided into normal control groups (KN) and diabetic groups. The diabetic group was streptozotocin-induced and divided further into three treatment groups: the diabetic control group (KD), the S. duplicatum treatment group (PA), and the combination of S. duplicatum and G. mangostana treatment group (PAM). The dose of treatment was 50 mg/kg of body weight. Each group was divided into three treatment durations, which were 3 days, 7 days, and 14 days. The wound healing process was determined by wound width, the number of neutrophils, macrophages, fibroblasts, fibrocytes, and collagen density. Histological observation showed that the topical administration of combination extracts increased the re-epithelialization of the wounded area, fibroblasts, fibrocytes, and collagen synthesis. The topical administration of combination extracts also decreased the number of neutrophils and macrophages. This study concluded that the topical administration of the combination of S. duplicatum and G. mangostana extracts improved the open wound healing process in diabetic mice.http://dx.doi.org/10.1155/2022/9700794 |
| spellingShingle | Dwi Winarni Fitria Nikmatul Husna Muhammad Farraz Syadzha Raden Joko Kuncoroningrat Susilo Suhailah Hayaza Arif Nur Muhammad Ansori Mochammad Amin Alamsjah Muhamad Nur Ghoyatul Amin Pugar Arga Christina Wulandari Pratiwi Pudjiastuti Khalijah Awang Topical Administration Effect of Sargassum duplicatum and Garcinia mangostana Extracts Combination on Open Wound Healing Process in Diabetic Mice Scientifica |
| title | Topical Administration Effect of Sargassum duplicatum and Garcinia mangostana Extracts Combination on Open Wound Healing Process in Diabetic Mice |
| title_full | Topical Administration Effect of Sargassum duplicatum and Garcinia mangostana Extracts Combination on Open Wound Healing Process in Diabetic Mice |
| title_fullStr | Topical Administration Effect of Sargassum duplicatum and Garcinia mangostana Extracts Combination on Open Wound Healing Process in Diabetic Mice |
| title_full_unstemmed | Topical Administration Effect of Sargassum duplicatum and Garcinia mangostana Extracts Combination on Open Wound Healing Process in Diabetic Mice |
| title_short | Topical Administration Effect of Sargassum duplicatum and Garcinia mangostana Extracts Combination on Open Wound Healing Process in Diabetic Mice |
| title_sort | topical administration effect of sargassum duplicatum and garcinia mangostana extracts combination on open wound healing process in diabetic mice |
| url | http://dx.doi.org/10.1155/2022/9700794 |
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