Fabrication of microcapsules with core‐shell structure for oral delivery of dual drugs and real‐time computed tomography imaging
Abstract Although multidrug combinations are an effective therapeutic strategy for serious disease in clinical practice, their therapeutic effect may be reduced because they conflict with each other medicinally in certain cases. Hence, there is an urgent need to develop a single drug carrier for pre...
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| Format: | Article |
| Language: | English |
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Wiley
2021-09-01
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| Series: | IET Nanobiotechnology |
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| Online Access: | https://doi.org/10.1049/nbt2.12058 |
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| author | Rong Cai Long Xiao Miaomiao Zhang Lulu Zhao Jingjing Zhang Fengyi Du Zhirong Wang |
| author_facet | Rong Cai Long Xiao Miaomiao Zhang Lulu Zhao Jingjing Zhang Fengyi Du Zhirong Wang |
| author_sort | Rong Cai |
| collection | DOAJ |
| description | Abstract Although multidrug combinations are an effective therapeutic strategy for serious disease in clinical practice, their therapeutic effect may be reduced because they conflict with each other medicinally in certain cases. Hence, there is an urgent need to develop a single drug carrier for precise multidrug delivery to avoid this interference. A reverse coordination method is reported that fabricates a double‐layer barium sulphate microcapsule (DL@BS MS) for two drugs separately loading simultaneously. In addition, BS nanoclusters were synthesised in situ inside the DL@BS MSs for real‐time computed tomography (CT) imaging. The results showed that the DL@BS MSs with a particle size of approximately 2 mm exhibited a uniform sphere. Because BS nanoclusters have a high X‐ray attenuation coefficient, the retention of DL@BS MSs in the digestive tract could be monitored through CT imaging in real time. More important, the core‐shell structure of DL@BS MSs encapsulating two different drugs could be released in spatiotemporal order in an acidic stomach environment. The as‐synthesis DL@BS MSs with a core‐shell structure and real‐time imaging performance provide an ideal carrier for the oral administration of multiple drugs simultaneously loaded but sequentially released. |
| format | Article |
| id | doaj-art-7e2046c3228b41bba87bcca140756045 |
| institution | Kabale University |
| issn | 1751-8741 1751-875X |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj-art-7e2046c3228b41bba87bcca1407560452025-02-03T06:47:26ZengWileyIET Nanobiotechnology1751-87411751-875X2021-09-0115761962610.1049/nbt2.12058Fabrication of microcapsules with core‐shell structure for oral delivery of dual drugs and real‐time computed tomography imagingRong Cai0Long Xiao1Miaomiao Zhang2Lulu Zhao3Jingjing Zhang4Fengyi Du5Zhirong Wang6Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Zhangjiagang Jiangsu ChinaZhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Zhangjiagang Jiangsu ChinaSchool of Medicine Jiangsu University Zhenjiang ChinaSchool of Medicine Jiangsu University Zhenjiang ChinaSchool of Medicine Jiangsu University Zhenjiang ChinaSchool of Medicine Jiangsu University Zhenjiang ChinaZhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Zhangjiagang Jiangsu ChinaAbstract Although multidrug combinations are an effective therapeutic strategy for serious disease in clinical practice, their therapeutic effect may be reduced because they conflict with each other medicinally in certain cases. Hence, there is an urgent need to develop a single drug carrier for precise multidrug delivery to avoid this interference. A reverse coordination method is reported that fabricates a double‐layer barium sulphate microcapsule (DL@BS MS) for two drugs separately loading simultaneously. In addition, BS nanoclusters were synthesised in situ inside the DL@BS MSs for real‐time computed tomography (CT) imaging. The results showed that the DL@BS MSs with a particle size of approximately 2 mm exhibited a uniform sphere. Because BS nanoclusters have a high X‐ray attenuation coefficient, the retention of DL@BS MSs in the digestive tract could be monitored through CT imaging in real time. More important, the core‐shell structure of DL@BS MSs encapsulating two different drugs could be released in spatiotemporal order in an acidic stomach environment. The as‐synthesis DL@BS MSs with a core‐shell structure and real‐time imaging performance provide an ideal carrier for the oral administration of multiple drugs simultaneously loaded but sequentially released.https://doi.org/10.1049/nbt2.12058biomedical materialscancercellular biophysicscomputerised tomographydiseasesdrug delivery systems |
| spellingShingle | Rong Cai Long Xiao Miaomiao Zhang Lulu Zhao Jingjing Zhang Fengyi Du Zhirong Wang Fabrication of microcapsules with core‐shell structure for oral delivery of dual drugs and real‐time computed tomography imaging IET Nanobiotechnology biomedical materials cancer cellular biophysics computerised tomography diseases drug delivery systems |
| title | Fabrication of microcapsules with core‐shell structure for oral delivery of dual drugs and real‐time computed tomography imaging |
| title_full | Fabrication of microcapsules with core‐shell structure for oral delivery of dual drugs and real‐time computed tomography imaging |
| title_fullStr | Fabrication of microcapsules with core‐shell structure for oral delivery of dual drugs and real‐time computed tomography imaging |
| title_full_unstemmed | Fabrication of microcapsules with core‐shell structure for oral delivery of dual drugs and real‐time computed tomography imaging |
| title_short | Fabrication of microcapsules with core‐shell structure for oral delivery of dual drugs and real‐time computed tomography imaging |
| title_sort | fabrication of microcapsules with core shell structure for oral delivery of dual drugs and real time computed tomography imaging |
| topic | biomedical materials cancer cellular biophysics computerised tomography diseases drug delivery systems |
| url | https://doi.org/10.1049/nbt2.12058 |
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