Chrysin attenuates hyperglycemia associated with hepatorenal and glycoprotein abnormalities via regulation of glucose metabolism in HFD/STZ- induced diabetic rats
Background: Flavonoids like chyrsin, which are abundant in plant extracts, honey, and bee propolis, have antiviral, anti-cancer, anti-bacterial, anti-inflammatory, anti-allergic, anti-mutagenic, anti-anxiolytic, and other therapeutic uses. However, no research has been published on how chrysin prote...
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Elsevier
2024-11-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031324001064 |
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| author | R. Sundaram K. Muthu |
| author_facet | R. Sundaram K. Muthu |
| author_sort | R. Sundaram |
| collection | DOAJ |
| description | Background: Flavonoids like chyrsin, which are abundant in plant extracts, honey, and bee propolis, have antiviral, anti-cancer, anti-bacterial, anti-inflammatory, anti-allergic, anti-mutagenic, anti-anxiolytic, and other therapeutic uses. However, no research has been published on how chrysin protects rats against HFD/STZ- induced changes to the glycoprotein moiety via controlling the metabolism of glucose. Methods: For two weeks, albino male wistar rats were fed a high-fat diet in order to develop diabetes. Upon two weeks, a low dosage of streptozotocin (35 mg/kg, diluted in 0.1 M sodium citrate buffer, pH 4.5) was administered into the animals after they had been fasted for the whole night. Blood glucose, insulin, hepatic, and renal indicators were analyzed using commercially available diagnostic kits, and other parameters were ascertained biochemically. Results: For 30 days, high-fat diet- and streptozotocin-induced diabetic rats were given 40 mg/kg b.w./day of chrysin, which significantly reduced blood glucose, homeostatic model assessment of insulin resistance, glycogen phospharylase, hepatic and renal markers, and increased insulin, glycogen content, and glycogen synthase levels. Conclusion: However, the altered activity of the glycoprotein components and the carbohydrate metabolic enzymes was restored upon chrysin administration. On several criteria, the chrysin's effect was similar to that of metformin. Chrysin is therefore a potential antidiabetic agent. |
| format | Article |
| id | doaj-art-7e1c9a793e5e4de0892d29a8834c3fa1 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-7e1c9a793e5e4de0892d29a8834c3fa12024-11-18T04:33:47ZengElsevierPhytomedicine Plus2667-03132024-11-0144100632Chrysin attenuates hyperglycemia associated with hepatorenal and glycoprotein abnormalities via regulation of glucose metabolism in HFD/STZ- induced diabetic ratsR. Sundaram0K. Muthu1Department of Biochemistry, Tagore Medical College & Hospital, Chennai - 600127, Tamil Nadu, India; Corresponding author at: Department of Biochemistry, Tagore Medical College & Hospital, Chennai-600127. India.Department of Chemistry, Manonmaniam Sundaranar University, Abishekapatti, Tirunelveli-627012, Tamil Nadu, IndiaBackground: Flavonoids like chyrsin, which are abundant in plant extracts, honey, and bee propolis, have antiviral, anti-cancer, anti-bacterial, anti-inflammatory, anti-allergic, anti-mutagenic, anti-anxiolytic, and other therapeutic uses. However, no research has been published on how chrysin protects rats against HFD/STZ- induced changes to the glycoprotein moiety via controlling the metabolism of glucose. Methods: For two weeks, albino male wistar rats were fed a high-fat diet in order to develop diabetes. Upon two weeks, a low dosage of streptozotocin (35 mg/kg, diluted in 0.1 M sodium citrate buffer, pH 4.5) was administered into the animals after they had been fasted for the whole night. Blood glucose, insulin, hepatic, and renal indicators were analyzed using commercially available diagnostic kits, and other parameters were ascertained biochemically. Results: For 30 days, high-fat diet- and streptozotocin-induced diabetic rats were given 40 mg/kg b.w./day of chrysin, which significantly reduced blood glucose, homeostatic model assessment of insulin resistance, glycogen phospharylase, hepatic and renal markers, and increased insulin, glycogen content, and glycogen synthase levels. Conclusion: However, the altered activity of the glycoprotein components and the carbohydrate metabolic enzymes was restored upon chrysin administration. On several criteria, the chrysin's effect was similar to that of metformin. Chrysin is therefore a potential antidiabetic agent.http://www.sciencedirect.com/science/article/pii/S2667031324001064ChrysinMetabolic enzymesInsulin resistantDiabetesNephropathy |
| spellingShingle | R. Sundaram K. Muthu Chrysin attenuates hyperglycemia associated with hepatorenal and glycoprotein abnormalities via regulation of glucose metabolism in HFD/STZ- induced diabetic rats Phytomedicine Plus Chrysin Metabolic enzymes Insulin resistant Diabetes Nephropathy |
| title | Chrysin attenuates hyperglycemia associated with hepatorenal and glycoprotein abnormalities via regulation of glucose metabolism in HFD/STZ- induced diabetic rats |
| title_full | Chrysin attenuates hyperglycemia associated with hepatorenal and glycoprotein abnormalities via regulation of glucose metabolism in HFD/STZ- induced diabetic rats |
| title_fullStr | Chrysin attenuates hyperglycemia associated with hepatorenal and glycoprotein abnormalities via regulation of glucose metabolism in HFD/STZ- induced diabetic rats |
| title_full_unstemmed | Chrysin attenuates hyperglycemia associated with hepatorenal and glycoprotein abnormalities via regulation of glucose metabolism in HFD/STZ- induced diabetic rats |
| title_short | Chrysin attenuates hyperglycemia associated with hepatorenal and glycoprotein abnormalities via regulation of glucose metabolism in HFD/STZ- induced diabetic rats |
| title_sort | chrysin attenuates hyperglycemia associated with hepatorenal and glycoprotein abnormalities via regulation of glucose metabolism in hfd stz induced diabetic rats |
| topic | Chrysin Metabolic enzymes Insulin resistant Diabetes Nephropathy |
| url | http://www.sciencedirect.com/science/article/pii/S2667031324001064 |
| work_keys_str_mv | AT rsundaram chrysinattenuateshyperglycemiaassociatedwithhepatorenalandglycoproteinabnormalitiesviaregulationofglucosemetabolisminhfdstzinduceddiabeticrats AT kmuthu chrysinattenuateshyperglycemiaassociatedwithhepatorenalandglycoproteinabnormalitiesviaregulationofglucosemetabolisminhfdstzinduceddiabeticrats |