Metabolic reprogramming of tumor-associated neutrophils in tumor treatment and therapeutic resistance

Metabolic reprogramming of tumor-associated neutrophils in tumor treatment and therapeutic resistance

Tumor-associated neutrophils (TANs), pivotal immune cells within the tumor microenvironment (TME), exhibit dual potential in both pro- and anti-tumorigenic effects. These cells display remarkable heterogeneity and plasticity within the TME, adapting to hypoxic and nutrient-deprived conditions throug...

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Bibliographic Details
Main Authors: Jun Lin, Xian-Lu He, Wei-Wei Zhang, Chun-Fen Mo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
tumor-associated neutrophils
tumor microenvironment
metabolic reprogramming
therapeutic resistance
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1584987/full
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