Comparative effectiveness of prophylactic antibiotic regimens in preventing infection in open fractures: a prospective cohort study

Comparative effectiveness of prophylactic antibiotic regimens in preventing infection in open fractures: a prospective cohort study

Abstract Background Open fractures, particularly Gustilo-Anderson grade III injuries, carry high risks of infection. This cohort study compared the effectiveness of three prophylactic antibiotic regimens in reducing a range of infection-related outcomes, including infection markers (ESR, CRP), wound...

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Main Authors: Mohammad Sheibani, Amirreza Sadeghifar, Shahriyar Shafa, Salman Azarsina, Mohammad Sajjad Mirhoseini, Mahdi Mohammaditabar, Elham al-Sadat Seyyed Ghasemi, Nima Rafati
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Musculoskeletal Disorders
Subjects:
Open fractures
Prophylactic antibiotics
Vancomycin
Cefazolin
Infection prevention
Cohort study
Online Access:https://doi.org/10.1186/s12891-025-09063-3
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