Case report: A case of severe capecitabine toxicity due to confirmed in trans compound heterozygosity of a common and rare DPYD variant

Case report: A case of severe capecitabine toxicity due to confirmed in trans compound heterozygosity of a common and rare DPYD variant

Variations in the activity of the enzyme dihydropyrimidine dehydrogenase (DPD) are associated with toxicity to fluoropyrimidine-containing chemotherapy. Testing of DPD deficiency either by targeted genotyping of the corresponding DPYD gene or by quantification of plasma concentration of uracil and d...

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Bibliographic Details
Main Authors: Amy de Haar-Holleman, Pieter-Jan Cortoos, Jelle Vlaeminck, Paulien Van Landuyt, Stephane Steurbaut, Freya Vaeyens, Vincent Haufroid
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Pharmacology
Subjects:
case report
capecitabine
DPYD gene polymorphism
pheno- and genotyping
rare variant
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1459565/full
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