Glioblastoma formation in a recurrent intracranial epidermoid cyst: a case report
Background: Transformation to glioblastoma following recurrent epidermoid cyst resection has not been reported. Chronic inflammation can underlie malignant transformation of epidermoid cysts. Astrogliosis following repeated resections may have induced the rare transformation to glioblastoma. Clinica...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-12-01
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| Series: | CNS Oncology |
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| Online Access: | https://www.futuremedicine.com/doi/10.2217/cns-2018-0002 |
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| author | Paul MacMahon Collin M Labak Sarah E Martin-Bach Ahmad Issawi Kiran Velpula Andrew J Tsung |
| author_facet | Paul MacMahon Collin M Labak Sarah E Martin-Bach Ahmad Issawi Kiran Velpula Andrew J Tsung |
| author_sort | Paul MacMahon |
| collection | DOAJ |
| description | Background: Transformation to glioblastoma following recurrent epidermoid cyst resection has not been reported. Chronic inflammation can underlie malignant transformation of epidermoid cysts. Astrogliosis following repeated resections may have induced the rare transformation to glioblastoma. Clinical presentation: A patient presenting with left lower extremity weakness was found to harbor a parietal mass lesion. Histopathology demonstrated an epidermoid cyst. Following multiple re-resections, an intra-axial mass was discovered within the operative bed, confirmed as glioblastoma. Conclusion: This is the first report of glioblastoma associated with a resected epidermoid cyst. Subsequent to resection, the chronic inflammatory milieu propagated by astrogliosis is thought to have induced malignancy. The progression to glioblastoma draws attention to neoplastic transformation in the context of recurrent epidermoids. |
| format | Article |
| id | doaj-art-7e154a75df224bffab79a47fa5765e88 |
| institution | OA Journals |
| issn | 2045-0907 2045-0915 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CNS Oncology |
| spelling | doaj-art-7e154a75df224bffab79a47fa5765e882025-08-20T02:26:02ZengTaylor & Francis GroupCNS Oncology2045-09072045-09152018-12-017410.2217/cns-2018-0002Glioblastoma formation in a recurrent intracranial epidermoid cyst: a case reportPaul MacMahon0Collin M Labak1Sarah E Martin-Bach2Ahmad Issawi3Kiran Velpula4Andrew J Tsung51Department of Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria, IL, 61605, USA3Department of Cancer Biology & Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL, 61605, USA4Department of Pathology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA1Department of Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria, IL, 61605, USA3Department of Cancer Biology & Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL, 61605, USA1Department of Neurosurgery, University of Illinois College of Medicine at Peoria, Peoria, IL, 61605, USABackground: Transformation to glioblastoma following recurrent epidermoid cyst resection has not been reported. Chronic inflammation can underlie malignant transformation of epidermoid cysts. Astrogliosis following repeated resections may have induced the rare transformation to glioblastoma. Clinical presentation: A patient presenting with left lower extremity weakness was found to harbor a parietal mass lesion. Histopathology demonstrated an epidermoid cyst. Following multiple re-resections, an intra-axial mass was discovered within the operative bed, confirmed as glioblastoma. Conclusion: This is the first report of glioblastoma associated with a resected epidermoid cyst. Subsequent to resection, the chronic inflammatory milieu propagated by astrogliosis is thought to have induced malignancy. The progression to glioblastoma draws attention to neoplastic transformation in the context of recurrent epidermoids.https://www.futuremedicine.com/doi/10.2217/cns-2018-0002epidermoid cystglioblastomamalignant transformation |
| spellingShingle | Paul MacMahon Collin M Labak Sarah E Martin-Bach Ahmad Issawi Kiran Velpula Andrew J Tsung Glioblastoma formation in a recurrent intracranial epidermoid cyst: a case report CNS Oncology epidermoid cyst glioblastoma malignant transformation |
| title | Glioblastoma formation in a recurrent intracranial epidermoid cyst: a case report |
| title_full | Glioblastoma formation in a recurrent intracranial epidermoid cyst: a case report |
| title_fullStr | Glioblastoma formation in a recurrent intracranial epidermoid cyst: a case report |
| title_full_unstemmed | Glioblastoma formation in a recurrent intracranial epidermoid cyst: a case report |
| title_short | Glioblastoma formation in a recurrent intracranial epidermoid cyst: a case report |
| title_sort | glioblastoma formation in a recurrent intracranial epidermoid cyst a case report |
| topic | epidermoid cyst glioblastoma malignant transformation |
| url | https://www.futuremedicine.com/doi/10.2217/cns-2018-0002 |
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