Research status and prospects of exosomes in the treatment of intervertebral disc degeneration
Intervertebral disc degeneration (IDD) is characterized pathologically by a reduction in nucleus pulposus cells, inflammation of the cartilaginous endplate, and annulus fibrosus rupture. Regenerative therapies aimed at restoring the normal physiological structure of the intervertebral disc have been...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Guangxi Medical University
2025-06-01
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| Series: | Guangxi Yike Daxue xuebao |
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| Online Access: | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2025.03.019 |
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| _version_ | 1850086625739014144 |
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| author | Feihong HUANG Hua JIANG |
| author_facet | Feihong HUANG Hua JIANG |
| author_sort | Feihong HUANG |
| collection | DOAJ |
| description | Intervertebral disc degeneration (IDD) is characterized pathologically by a reduction in nucleus pulposus cells, inflammation of the cartilaginous endplate, and annulus fibrosus rupture. Regenerative therapies aimed at restoring the normal physiological structure of the intervertebral disc have been a focus of research, with exosome (Exo) therapy receiving considerable attention in recent years. Many studies have shown that Exos exert therapeutic effects on IDD by maintaining extracellular matrix homeostasis, inhibiting cell apoptosis, and exhibiting antioxidant and anti-inflammatory properties, thereby restoring the structural and functional characteristics of degenerated intervertebral discs. This review summarizes the current research status of Exos from different cellular sources in the field of IDD treatment, analyzes the advantages and disadvantages of Exos compared to various biological therapies, and discusses the future prospects of Exo therapy. |
| format | Article |
| id | doaj-art-7e148398fcc04d22bb2824f72bcfe67a |
| institution | DOAJ |
| issn | 1005-930X |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Editorial Office of Journal of Guangxi Medical University |
| record_format | Article |
| series | Guangxi Yike Daxue xuebao |
| spelling | doaj-art-7e148398fcc04d22bb2824f72bcfe67a2025-08-20T02:43:25ZzhoEditorial Office of Journal of Guangxi Medical UniversityGuangxi Yike Daxue xuebao1005-930X2025-06-0142346447010.16190/j.cnki.45-1211/r.2025.03.019gxykdxxb-42-3-464Research status and prospects of exosomes in the treatment of intervertebral disc degenerationFeihong HUANG0Hua JIANG1Department of Spinal Surgery and Orthopaedics, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Spinal Surgery and Orthopaedics, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaIntervertebral disc degeneration (IDD) is characterized pathologically by a reduction in nucleus pulposus cells, inflammation of the cartilaginous endplate, and annulus fibrosus rupture. Regenerative therapies aimed at restoring the normal physiological structure of the intervertebral disc have been a focus of research, with exosome (Exo) therapy receiving considerable attention in recent years. Many studies have shown that Exos exert therapeutic effects on IDD by maintaining extracellular matrix homeostasis, inhibiting cell apoptosis, and exhibiting antioxidant and anti-inflammatory properties, thereby restoring the structural and functional characteristics of degenerated intervertebral discs. This review summarizes the current research status of Exos from different cellular sources in the field of IDD treatment, analyzes the advantages and disadvantages of Exos compared to various biological therapies, and discusses the future prospects of Exo therapy.https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2025.03.019exosomesintervertebral disc degenerationtreatment methodsstem cells |
| spellingShingle | Feihong HUANG Hua JIANG Research status and prospects of exosomes in the treatment of intervertebral disc degeneration Guangxi Yike Daxue xuebao exosomes intervertebral disc degeneration treatment methods stem cells |
| title | Research status and prospects of exosomes in the treatment of intervertebral disc degeneration |
| title_full | Research status and prospects of exosomes in the treatment of intervertebral disc degeneration |
| title_fullStr | Research status and prospects of exosomes in the treatment of intervertebral disc degeneration |
| title_full_unstemmed | Research status and prospects of exosomes in the treatment of intervertebral disc degeneration |
| title_short | Research status and prospects of exosomes in the treatment of intervertebral disc degeneration |
| title_sort | research status and prospects of exosomes in the treatment of intervertebral disc degeneration |
| topic | exosomes intervertebral disc degeneration treatment methods stem cells |
| url | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2025.03.019 |
| work_keys_str_mv | AT feihonghuang researchstatusandprospectsofexosomesinthetreatmentofintervertebraldiscdegeneration AT huajiang researchstatusandprospectsofexosomesinthetreatmentofintervertebraldiscdegeneration |