Severe Quantitative Scale of Acanthosis Nigricans in Neck is Associated with Abdominal Obesity, HOMA-IR, and Hyperlipidemia in Obese Children from Mexico City: A Cross-Sectional Study
Background. Acanthosis nigricans (AN) is a clinical sign that commonly occurs in obesity; however, its specificity and sensitivity have been controversial. It is unknown if AN severity degree can be a useful marker for cardiometabolic disorders screening. We suggest that the stratified analysis of A...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/2906189 |
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| author | Ana I. Burguete-García Alan Gilberto Ramírez Valverde Meztli Espinoza-León Isaac Sánchez Vázquez Evelyn Yazmín Estrada Ramírez Itzel Maldonado-López Alfredo Lagunas Martínez Cinthya Estefhany Diaz Benítez Roberto Karam Araujo Diana Fernández-Madinaveitia Adriana E. Anides Fonseca Miguel Cruz José de Jesús Peralta Romero |
| author_facet | Ana I. Burguete-García Alan Gilberto Ramírez Valverde Meztli Espinoza-León Isaac Sánchez Vázquez Evelyn Yazmín Estrada Ramírez Itzel Maldonado-López Alfredo Lagunas Martínez Cinthya Estefhany Diaz Benítez Roberto Karam Araujo Diana Fernández-Madinaveitia Adriana E. Anides Fonseca Miguel Cruz José de Jesús Peralta Romero |
| author_sort | Ana I. Burguete-García |
| collection | DOAJ |
| description | Background. Acanthosis nigricans (AN) is a clinical sign that commonly occurs in obesity; however, its specificity and sensitivity have been controversial. It is unknown if AN severity degree can be a useful marker for cardiometabolic disorders screening. We suggest that the stratified analysis of AN severity degree in neck by Burke’s scale could be a useful tool in the screening of cardiometabolic alterations in obese children. Objective. The aim of this study was the association of AN severity degree in neck by Burke’s scale with anthropometric, biochemical, and inflammatory parameters in obese school-age children from Mexico City. Methods. A cross-sectional study was conducted, including 95 obese school-age children stratified by AN severity degree in neck by Burke’s scale. Anthropometric and fasting biochemical measurements were determined. Variables were compared by x2 test for frequencies and one-way ANOVA with Bonferroni posttest for continuous variables. Linear regression analysis adjusted by gender, BMI, and age was performed to evaluate the association between AN severity degree and cardiometabolic alterations. Statistical significance was set at p<0.05. Results. As AN severity degree in neck by Burke’s scale increased, diastolic blood pressure (p=0.001) and triglycerides (p=0.02) significantly increased and adiponectin significantly decreased (p=0.02). Positive associations between grade 3 AN and waist circumference, HOMA-IR, triglycerides, total cholesterol, and LDL cholesterol were observed. Conclusion. Our findings could be used to identify an easier clinical tool to prevent obesity progression and its complications in pediatrics. There are no similar studies. |
| format | Article |
| id | doaj-art-7e115742ec824fc0aa6df84ffc4f6d59 |
| institution | Kabale University |
| issn | 1687-6113 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
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| series | Dermatology Research and Practice |
| spelling | doaj-art-7e115742ec824fc0aa6df84ffc4f6d592025-08-20T03:35:33ZengWileyDermatology Research and Practice1687-61132022-01-01202210.1155/2022/2906189Severe Quantitative Scale of Acanthosis Nigricans in Neck is Associated with Abdominal Obesity, HOMA-IR, and Hyperlipidemia in Obese Children from Mexico City: A Cross-Sectional StudyAna I. Burguete-García0Alan Gilberto Ramírez Valverde1Meztli Espinoza-León2Isaac Sánchez Vázquez3Evelyn Yazmín Estrada Ramírez4Itzel Maldonado-López5Alfredo Lagunas Martínez6Cinthya Estefhany Diaz Benítez7Roberto Karam Araujo8Diana Fernández-Madinaveitia9Adriana E. Anides Fonseca10Miguel Cruz11José de Jesús Peralta Romero12Departamento de Infecciones Crónicas y CáncerUnidad de Investigación Médica en BioquímicaUnidad de Investigación Médica en BioquímicaUnidad de Investigación Médica en BioquímicaUnidad de Investigación Médica en BioquímicaUnidad de Investigación Médica en BioquímicaDepartamento de Infecciones Crónicas y CáncerDepartamento de Infecciones Crónicas y CáncerDepartamento de Prestaciones Económicas y Sociales Del Instituto Mexicano del Seguro SocialUnidad de DermatologíaUnidad de DermatologíaUnidad de Investigación Médica en BioquímicaUnidad de Investigación Médica en BioquímicaBackground. Acanthosis nigricans (AN) is a clinical sign that commonly occurs in obesity; however, its specificity and sensitivity have been controversial. It is unknown if AN severity degree can be a useful marker for cardiometabolic disorders screening. We suggest that the stratified analysis of AN severity degree in neck by Burke’s scale could be a useful tool in the screening of cardiometabolic alterations in obese children. Objective. The aim of this study was the association of AN severity degree in neck by Burke’s scale with anthropometric, biochemical, and inflammatory parameters in obese school-age children from Mexico City. Methods. A cross-sectional study was conducted, including 95 obese school-age children stratified by AN severity degree in neck by Burke’s scale. Anthropometric and fasting biochemical measurements were determined. Variables were compared by x2 test for frequencies and one-way ANOVA with Bonferroni posttest for continuous variables. Linear regression analysis adjusted by gender, BMI, and age was performed to evaluate the association between AN severity degree and cardiometabolic alterations. Statistical significance was set at p<0.05. Results. As AN severity degree in neck by Burke’s scale increased, diastolic blood pressure (p=0.001) and triglycerides (p=0.02) significantly increased and adiponectin significantly decreased (p=0.02). Positive associations between grade 3 AN and waist circumference, HOMA-IR, triglycerides, total cholesterol, and LDL cholesterol were observed. Conclusion. Our findings could be used to identify an easier clinical tool to prevent obesity progression and its complications in pediatrics. There are no similar studies.http://dx.doi.org/10.1155/2022/2906189 |
| spellingShingle | Ana I. Burguete-García Alan Gilberto Ramírez Valverde Meztli Espinoza-León Isaac Sánchez Vázquez Evelyn Yazmín Estrada Ramírez Itzel Maldonado-López Alfredo Lagunas Martínez Cinthya Estefhany Diaz Benítez Roberto Karam Araujo Diana Fernández-Madinaveitia Adriana E. Anides Fonseca Miguel Cruz José de Jesús Peralta Romero Severe Quantitative Scale of Acanthosis Nigricans in Neck is Associated with Abdominal Obesity, HOMA-IR, and Hyperlipidemia in Obese Children from Mexico City: A Cross-Sectional Study Dermatology Research and Practice |
| title | Severe Quantitative Scale of Acanthosis Nigricans in Neck is Associated with Abdominal Obesity, HOMA-IR, and Hyperlipidemia in Obese Children from Mexico City: A Cross-Sectional Study |
| title_full | Severe Quantitative Scale of Acanthosis Nigricans in Neck is Associated with Abdominal Obesity, HOMA-IR, and Hyperlipidemia in Obese Children from Mexico City: A Cross-Sectional Study |
| title_fullStr | Severe Quantitative Scale of Acanthosis Nigricans in Neck is Associated with Abdominal Obesity, HOMA-IR, and Hyperlipidemia in Obese Children from Mexico City: A Cross-Sectional Study |
| title_full_unstemmed | Severe Quantitative Scale of Acanthosis Nigricans in Neck is Associated with Abdominal Obesity, HOMA-IR, and Hyperlipidemia in Obese Children from Mexico City: A Cross-Sectional Study |
| title_short | Severe Quantitative Scale of Acanthosis Nigricans in Neck is Associated with Abdominal Obesity, HOMA-IR, and Hyperlipidemia in Obese Children from Mexico City: A Cross-Sectional Study |
| title_sort | severe quantitative scale of acanthosis nigricans in neck is associated with abdominal obesity homa ir and hyperlipidemia in obese children from mexico city a cross sectional study |
| url | http://dx.doi.org/10.1155/2022/2906189 |
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