Targeting DKC1/NF-κB axis suppresses tumorigenesis and enhances 5-FU sensitivity in gastric cancer

Targeting DKC1/NF-κB axis suppresses tumorigenesis and enhances 5-FU sensitivity in gastric cancer

Abstract Background Gastric cancer (GC), an aggressive malignant tumor with poor overall survival worldwide, urgently requires novel diagnostic and therapeutic targets. The dyskeratosis congenita 1 (DKC1) gene has been reported to have diverse biological functions and prognostic values in several ty...

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Bibliographic Details
Main Authors: Tengkai wang, Hui Zhang, Yaoyao Feng, Yinrong Yang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
DKC1
5-FU
Gastric cancer
NFκB
Therapeutic target
Online Access:https://doi.org/10.1186/s12935-025-03926-4
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