The relationship between hysterectomy, menopause, and tubal ligation, with coronary heart diseases in North of Iran: a population-based case–control study
Abstract Previously, menopause, hysterectomy, and tubal ligation (TL) have been evaluated as coronary heart disease (CHD) risk factors. However, the results regarding the significance of these associations were conflicting. Thus, the present study aimed to assess whether hysterectomy, menopause, and...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-03480-z |
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| author | Mehran Asadi-Aliabadi Mahmood Moosazadeh Kiarash Shakeriastani Mohammadmehdi Pejman Mobina Gheibi Maliheh Ghasemi Tirtashi Erfan Ghadirzadeh |
| author_facet | Mehran Asadi-Aliabadi Mahmood Moosazadeh Kiarash Shakeriastani Mohammadmehdi Pejman Mobina Gheibi Maliheh Ghasemi Tirtashi Erfan Ghadirzadeh |
| author_sort | Mehran Asadi-Aliabadi |
| collection | DOAJ |
| description | Abstract Previously, menopause, hysterectomy, and tubal ligation (TL) have been evaluated as coronary heart disease (CHD) risk factors. However, the results regarding the significance of these associations were conflicting. Thus, the present study aimed to assess whether hysterectomy, menopause, and TL increase the odds of CHD. This case-control study included data from the enrollment phase of the Tabari cohort study (TCS) consisting of 564 cases of CHD and 564 healthy controls. Logistic regression was used to calculate the odds ratio (OR) of CHD in relation to hysterectomy, menopause, and TL status after adjustment for confounders. The univariate logistic regression analysis showed a significantly higher odds of CHD among post-menopausal participants (OR: 5.09, 95%CI 3.92–6.61), participants with TL (OR: 1.81, 95%CI 1.41–2.32), and women with hysterectomy (OR: 2.43, 95%CI 1.69–3.50). However, none of the associations were statistically significant (Hysterectomy: OR: 1.21, 95%CI 0.8–1.85; Menopause: OR: 1.43, 95%CI 0.88–2.31; TL: OR: 1.01, 95%CI 0.74–1.37) in the fully adjusted model (after adjustment for age, diabetes, hypertension, residential area, waist-to-hip ratio, pregnancy number, socio-economic state, occupation, education, and physical activity). Although some models showed significance, none of the reproductive factors showed a significant association with CHD after full adjustment. |
| format | Article |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-7e0fd81c6f5040a8a0f7f26e2f074ee52025-08-20T03:22:02ZengNature PortfolioScientific Reports2045-23222025-05-011511810.1038/s41598-025-03480-zThe relationship between hysterectomy, menopause, and tubal ligation, with coronary heart diseases in North of Iran: a population-based case–control studyMehran Asadi-Aliabadi0Mahmood Moosazadeh1Kiarash Shakeriastani2Mohammadmehdi Pejman3Mobina Gheibi4Maliheh Ghasemi Tirtashi5Erfan Ghadirzadeh6Health Sciences Research Center, Mazandaran University of Medical SciencesGastrointestitional Cancer Research Center, Non-Communicable Disease Institute, Mazandaran University of Medical SciencesStudent Research Committee, School of Medicine, Mazandaran University of Medical SciencesStudent Research Committee, Kerman University of Medical SciencesStudent Research Committee, School of Allied Medical Sciences, Mazandaran University of Medical SciencesDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mazandaran University of Medical SciencesStudent Research Committee, School of Medicine, Mazandaran University of Medical SciencesAbstract Previously, menopause, hysterectomy, and tubal ligation (TL) have been evaluated as coronary heart disease (CHD) risk factors. However, the results regarding the significance of these associations were conflicting. Thus, the present study aimed to assess whether hysterectomy, menopause, and TL increase the odds of CHD. This case-control study included data from the enrollment phase of the Tabari cohort study (TCS) consisting of 564 cases of CHD and 564 healthy controls. Logistic regression was used to calculate the odds ratio (OR) of CHD in relation to hysterectomy, menopause, and TL status after adjustment for confounders. The univariate logistic regression analysis showed a significantly higher odds of CHD among post-menopausal participants (OR: 5.09, 95%CI 3.92–6.61), participants with TL (OR: 1.81, 95%CI 1.41–2.32), and women with hysterectomy (OR: 2.43, 95%CI 1.69–3.50). However, none of the associations were statistically significant (Hysterectomy: OR: 1.21, 95%CI 0.8–1.85; Menopause: OR: 1.43, 95%CI 0.88–2.31; TL: OR: 1.01, 95%CI 0.74–1.37) in the fully adjusted model (after adjustment for age, diabetes, hypertension, residential area, waist-to-hip ratio, pregnancy number, socio-economic state, occupation, education, and physical activity). Although some models showed significance, none of the reproductive factors showed a significant association with CHD after full adjustment.https://doi.org/10.1038/s41598-025-03480-zCoronary heart diseaseHysterectomyMenopauseTubal ligationRisk factorCohort |
| spellingShingle | Mehran Asadi-Aliabadi Mahmood Moosazadeh Kiarash Shakeriastani Mohammadmehdi Pejman Mobina Gheibi Maliheh Ghasemi Tirtashi Erfan Ghadirzadeh The relationship between hysterectomy, menopause, and tubal ligation, with coronary heart diseases in North of Iran: a population-based case–control study Scientific Reports Coronary heart disease Hysterectomy Menopause Tubal ligation Risk factor Cohort |
| title | The relationship between hysterectomy, menopause, and tubal ligation, with coronary heart diseases in North of Iran: a population-based case–control study |
| title_full | The relationship between hysterectomy, menopause, and tubal ligation, with coronary heart diseases in North of Iran: a population-based case–control study |
| title_fullStr | The relationship between hysterectomy, menopause, and tubal ligation, with coronary heart diseases in North of Iran: a population-based case–control study |
| title_full_unstemmed | The relationship between hysterectomy, menopause, and tubal ligation, with coronary heart diseases in North of Iran: a population-based case–control study |
| title_short | The relationship between hysterectomy, menopause, and tubal ligation, with coronary heart diseases in North of Iran: a population-based case–control study |
| title_sort | relationship between hysterectomy menopause and tubal ligation with coronary heart diseases in north of iran a population based case control study |
| topic | Coronary heart disease Hysterectomy Menopause Tubal ligation Risk factor Cohort |
| url | https://doi.org/10.1038/s41598-025-03480-z |
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