Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease
Aim. Current recommendations of the Russian Gastroenterological Association are developed to acquaint medical practitioners with modern diagnostics, treatment and trends in rational drug therapy for gastroesophageal reflux disease (GERD).General provisions. Incidence rate of GERD in the Russian Fede...
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Gastro LLC
2020-09-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/513 |
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| author | V. T. Ivashkin I. V. Maev A. S. Trukhmanov T. L. Lapina O. A. Storonova O. V. Zayratyants O. B. Dronova Yu. A. Kucheryavyy S. S. Pirogov R. G. Sayfutdinov Yu. P. Uspenskiy A. A. Sheptulin D. N. Andreev D. E. Rumyantseva |
| author_facet | V. T. Ivashkin I. V. Maev A. S. Trukhmanov T. L. Lapina O. A. Storonova O. V. Zayratyants O. B. Dronova Yu. A. Kucheryavyy S. S. Pirogov R. G. Sayfutdinov Yu. P. Uspenskiy A. A. Sheptulin D. N. Andreev D. E. Rumyantseva |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | Aim. Current recommendations of the Russian Gastroenterological Association are developed to acquaint medical practitioners with modern diagnostics, treatment and trends in rational drug therapy for gastroesophageal reflux disease (GERD).General provisions. Incidence rate of GERD in the Russian Federation varies from 11.3 to 23.6%. GERD is diagnosed with medical history and laboratory examination evidence. Esophagogastroduodenoscopy (EGDS) allows detection of reflux esophagitis of various severity and cylindrical epithelial metaplasia of esophagus. The refractory form of disease (lack of conclusive clinical and endoscopic remission during 4-8 weeks of standard-dose PPI therapy), presence of strictures and Barrett's esophagus require EGDS with esophageal biopsy and bioptic histological examination. Patients should be conclusively performed esophageal 24-hour pH-metry or pH-impedance monitoring, high-resolution manometry to thoroughly examine functionality of esophagus, esophagogastric junction and assess disease prognosis and therapy outcomes.Treatment of GERD should be personalised accounting for clinical manifestations and severity, as well as aimed at symptom improvement, lesion healing in erosive esophagitis, averting complications, Barrett's esophagus progression, dysplasia and esophageal adenocarcinoma.Proton pump inhibitors (PPIs) are most effective agents in primary (4-8 weeks) and maintenance anti-GERD therapy. Antacids are recommended in monotherapy for occasional nonerosive heartburn and complex anti-GERD settings for fast symptom improvement. Prokinetics can be used in combination with PPIs for their properties to recover normal functionality of esophagus through affecting pathogenetic mechanisms of GERD.Complicated patients (repeated bleedings, peptic esophageal strictures) are recommended anti-reflux surgery with prior examination of esophageal functionality using pH-impedance and high-resolution manometry.Conclusion. Current recommendations provide an up-to-date evidential medicial review of GERD and guidelines to advance special medical care and timely preventive measures. |
| format | Article |
| id | doaj-art-7e0c5f26e2c847198b0a756ad4db4d72 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2020-09-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-7e0c5f26e2c847198b0a756ad4db4d722025-02-10T16:14:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732020-09-01304709710.22416/1382-4376-2020-30-4-70-97382Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux DiseaseV. T. Ivashkin0I. V. Maev1A. S. Trukhmanov2T. L. Lapina3O. A. Storonova4O. V. Zayratyants5O. B. Dronova6Yu. A. Kucheryavyy7S. S. Pirogov8R. G. Sayfutdinov9Yu. P. Uspenskiy10A. A. Sheptulin11D. N. Andreev12D. E. Rumyantseva13Sechenov First Moscow State Medical University (Sechenov University)Moscow State University of Medicine and DentistrySechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Moscow State University of Medicine and DentistryOrenburg State Medical UniversityMoscow State University of Medicine and DentistryHerzen Moscow Oncology Research Center — Branch of the National Medical Research Radiology CenterKazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional EducationSaint-Petersburg State Pediatric Medical UniversitySechenov First Moscow State Medical University (Sechenov University)Moscow State University of Medicine and DentistrySechenov First Moscow State Medical University (Sechenov University)Aim. Current recommendations of the Russian Gastroenterological Association are developed to acquaint medical practitioners with modern diagnostics, treatment and trends in rational drug therapy for gastroesophageal reflux disease (GERD).General provisions. Incidence rate of GERD in the Russian Federation varies from 11.3 to 23.6%. GERD is diagnosed with medical history and laboratory examination evidence. Esophagogastroduodenoscopy (EGDS) allows detection of reflux esophagitis of various severity and cylindrical epithelial metaplasia of esophagus. The refractory form of disease (lack of conclusive clinical and endoscopic remission during 4-8 weeks of standard-dose PPI therapy), presence of strictures and Barrett's esophagus require EGDS with esophageal biopsy and bioptic histological examination. Patients should be conclusively performed esophageal 24-hour pH-metry or pH-impedance monitoring, high-resolution manometry to thoroughly examine functionality of esophagus, esophagogastric junction and assess disease prognosis and therapy outcomes.Treatment of GERD should be personalised accounting for clinical manifestations and severity, as well as aimed at symptom improvement, lesion healing in erosive esophagitis, averting complications, Barrett's esophagus progression, dysplasia and esophageal adenocarcinoma.Proton pump inhibitors (PPIs) are most effective agents in primary (4-8 weeks) and maintenance anti-GERD therapy. Antacids are recommended in monotherapy for occasional nonerosive heartburn and complex anti-GERD settings for fast symptom improvement. Prokinetics can be used in combination with PPIs for their properties to recover normal functionality of esophagus through affecting pathogenetic mechanisms of GERD.Complicated patients (repeated bleedings, peptic esophageal strictures) are recommended anti-reflux surgery with prior examination of esophageal functionality using pH-impedance and high-resolution manometry.Conclusion. Current recommendations provide an up-to-date evidential medicial review of GERD and guidelines to advance special medical care and timely preventive measures.https://www.gastro-j.ru/jour/article/view/513gastroesophageal reflux diseasegastroesophageal refluxnonerosive reflux diseasereflux esophagitisbarrett's esophagushigh-resolution manometryph-impedance monitoring |
| spellingShingle | V. T. Ivashkin I. V. Maev A. S. Trukhmanov T. L. Lapina O. A. Storonova O. V. Zayratyants O. B. Dronova Yu. A. Kucheryavyy S. S. Pirogov R. G. Sayfutdinov Yu. P. Uspenskiy A. A. Sheptulin D. N. Andreev D. E. Rumyantseva Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии gastroesophageal reflux disease gastroesophageal reflux nonerosive reflux disease reflux esophagitis barrett's esophagus high-resolution manometry ph-impedance monitoring |
| title | Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease |
| title_full | Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease |
| title_fullStr | Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease |
| title_full_unstemmed | Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease |
| title_short | Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease |
| title_sort | recommendations of the russian gastroenterological association in diagnosis and treatment of gastroesophageal reflux disease |
| topic | gastroesophageal reflux disease gastroesophageal reflux nonerosive reflux disease reflux esophagitis barrett's esophagus high-resolution manometry ph-impedance monitoring |
| url | https://www.gastro-j.ru/jour/article/view/513 |
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