Mechanism of ferroptosis and its role in kidney diseases
Regulatory cell death（RCD） is essential for the development of organisms and the maintenance of homeostasis.Previously apoptosis was deemed as a sole form of RCD.However, recent studies have demonstrated that RCD could proceed through apoptosis or one of several non-apoptotic cell death pathways, in...
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Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57903397&Fpath=home&index=0 |
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| author | Gong Mei-ling Li Jun-hua |
| author_facet | Gong Mei-ling Li Jun-hua |
| author_sort | Gong Mei-ling |
| collection | DOAJ |
| description | Regulatory cell death（RCD） is essential for the development of organisms and the maintenance of homeostasis.Previously apoptosis was deemed as a sole form of RCD.However, recent studies have demonstrated that RCD could proceed through apoptosis or one of several non-apoptotic cell death pathways, including recently described ferroptosis and pyroptosis.Ferroptosis is a new form of cell death in nerve cell injury.Triggered by an inactivation of glutathione（GSH） dependent antioxidant defense system, it results in an accumulation of lipid peroxidation products and reactive oxygen species（ROS）.The latest evidence has indicated that ferroptosis was correlated with acute kidney injury（AKI）,chronic kidney disease（CKD）,polycystic kidney disease and renal cell carcinoma（RCC）,etc.And the development of related kidney disease could be intervened by activating or inhibiting ferroptosis.This review examined the discovery, characteristics and mechanism of ferroptosis and its relationship with kidney diseases, summarized the major regulatory mechanisms of ferroptosis and explained the relationship between ferroptosis and kidney disease to provide a new potential therapeutic target for kidney disease. |
| format | Article |
| id | doaj-art-7e0af5d80d7c4db693b76642c1c7e6fb |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2021-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-7e0af5d80d7c4db693b76642c1c7e6fb2025-08-20T02:28:54ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902021-01-01211028103357903397Mechanism of ferroptosis and its role in kidney diseasesGong Mei-lingLi Jun-huaRegulatory cell death（RCD） is essential for the development of organisms and the maintenance of homeostasis.Previously apoptosis was deemed as a sole form of RCD.However, recent studies have demonstrated that RCD could proceed through apoptosis or one of several non-apoptotic cell death pathways, including recently described ferroptosis and pyroptosis.Ferroptosis is a new form of cell death in nerve cell injury.Triggered by an inactivation of glutathione（GSH） dependent antioxidant defense system, it results in an accumulation of lipid peroxidation products and reactive oxygen species（ROS）.The latest evidence has indicated that ferroptosis was correlated with acute kidney injury（AKI）,chronic kidney disease（CKD）,polycystic kidney disease and renal cell carcinoma（RCC）,etc.And the development of related kidney disease could be intervened by activating or inhibiting ferroptosis.This review examined the discovery, characteristics and mechanism of ferroptosis and its relationship with kidney diseases, summarized the major regulatory mechanisms of ferroptosis and explained the relationship between ferroptosis and kidney disease to provide a new potential therapeutic target for kidney disease.http://www.lcszb.com/thesisDetails?columnId=57903397&Fpath=home&index=0FerroptosisGlutathioneGlutathione Peroxidase4Iron metabolismKidney diseases |
| spellingShingle | Gong Mei-ling Li Jun-hua Mechanism of ferroptosis and its role in kidney diseases Linchuang shenzangbing zazhi Ferroptosis Glutathione Glutathione Peroxidase4 Iron metabolism Kidney diseases |
| title | Mechanism of ferroptosis and its role in kidney diseases |
| title_full | Mechanism of ferroptosis and its role in kidney diseases |
| title_fullStr | Mechanism of ferroptosis and its role in kidney diseases |
| title_full_unstemmed | Mechanism of ferroptosis and its role in kidney diseases |
| title_short | Mechanism of ferroptosis and its role in kidney diseases |
| title_sort | mechanism of ferroptosis and its role in kidney diseases |
| topic | Ferroptosis Glutathione Glutathione Peroxidase4 Iron metabolism Kidney diseases |
| url | http://www.lcszb.com/thesisDetails?columnId=57903397&Fpath=home&index=0 |
| work_keys_str_mv | AT gongmeiling mechanismofferroptosisanditsroleinkidneydiseases AT lijunhua mechanismofferroptosisanditsroleinkidneydiseases |