Incidence and Characteristics of Pediatric Eosinophilic Esophagitis: A Midwestern State Analysis
Background: Eosinophilic esophagitis (EoE) is a chronic disease defined by esophageal dysfunction and >15 eosinophils per high-power-field on biopsy. Despite its increased incidence across the United States, studies evaluating its incidence at any state level are lacking. Methods: Record review o...
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MDPI AG
2025-02-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/12/2/248 |
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| author | Jose L. Zamora-Sifuentes Andrew Rorie Sharad Kunnath Rosemary Pauley Andrew Huang Pacheco Russell Hopp |
| author_facet | Jose L. Zamora-Sifuentes Andrew Rorie Sharad Kunnath Rosemary Pauley Andrew Huang Pacheco Russell Hopp |
| author_sort | Jose L. Zamora-Sifuentes |
| collection | DOAJ |
| description | Background: Eosinophilic esophagitis (EoE) is a chronic disease defined by esophageal dysfunction and >15 eosinophils per high-power-field on biopsy. Despite its increased incidence across the United States, studies evaluating its incidence at any state level are lacking. Methods: Record review of pediatric patients (<18 years) newly diagnosed with EoE based on ICD coding seen at the main two pediatric gastroenterology centers in the state: Children’s Nebraska (1 January 2016–31 December 2022) and Boys Town National Research Hospital (1 January 2022–31 December 2022). Data included demographics, age, and zip codes. Descriptive analysis focused on Nebraska residents. Results: The average point incidence of EoE between 2016 and 2022 was 10.84/100,000 inhabitants based on data from Children’s Nebraska. Considering both centers, the point incidence in Nebraska for 2022 was 32.45/100,000 inhabitants. Caucasians were 3.7 times more likely to be affected and older at time of diagnosis (average 9.7 years) compared to African Americans (7.0), Hispanics (7.4), and Asians (4.4). Conclusions: This is the first study evaluating the incidence of EoE in a specific U.S.A state. Studies at the state level are important to direct policy and interventions aiming limit its burden in communities. |
| format | Article |
| id | doaj-art-7e04839ce29f45208ce06f89ff5c68b4 |
| institution | DOAJ |
| issn | 2227-9067 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Children |
| spelling | doaj-art-7e04839ce29f45208ce06f89ff5c68b42025-08-20T03:12:02ZengMDPI AGChildren2227-90672025-02-0112224810.3390/children12020248Incidence and Characteristics of Pediatric Eosinophilic Esophagitis: A Midwestern State AnalysisJose L. Zamora-Sifuentes0Andrew Rorie1Sharad Kunnath2Rosemary Pauley3Andrew Huang Pacheco4Russell Hopp5Division of Allergy & Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USADivision of Allergy & Immunology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USADivision of Gastroenterology, Department of Pediatrics, Boys Town National Research Hospital, Omaha, NE 68010, USADivision of Gastroenterology, Department of Pediatrics, Boys Town National Research Hospital, Omaha, NE 68010, USADivision of Gastroenterology, Department of Pediatrics, Children’s Nebraska, Omaha, NE 68114, USADivision of Pulmonology, Allergy & Sleep Medicine, Department of Pediatrics, Children’s Nebraska, Omaha, NE 68114, USABackground: Eosinophilic esophagitis (EoE) is a chronic disease defined by esophageal dysfunction and >15 eosinophils per high-power-field on biopsy. Despite its increased incidence across the United States, studies evaluating its incidence at any state level are lacking. Methods: Record review of pediatric patients (<18 years) newly diagnosed with EoE based on ICD coding seen at the main two pediatric gastroenterology centers in the state: Children’s Nebraska (1 January 2016–31 December 2022) and Boys Town National Research Hospital (1 January 2022–31 December 2022). Data included demographics, age, and zip codes. Descriptive analysis focused on Nebraska residents. Results: The average point incidence of EoE between 2016 and 2022 was 10.84/100,000 inhabitants based on data from Children’s Nebraska. Considering both centers, the point incidence in Nebraska for 2022 was 32.45/100,000 inhabitants. Caucasians were 3.7 times more likely to be affected and older at time of diagnosis (average 9.7 years) compared to African Americans (7.0), Hispanics (7.4), and Asians (4.4). Conclusions: This is the first study evaluating the incidence of EoE in a specific U.S.A state. Studies at the state level are important to direct policy and interventions aiming limit its burden in communities.https://www.mdpi.com/2227-9067/12/2/248Eosinophilic esophagitisEoEpediatricseosinophilic gastrointestinal diseasesEGID |
| spellingShingle | Jose L. Zamora-Sifuentes Andrew Rorie Sharad Kunnath Rosemary Pauley Andrew Huang Pacheco Russell Hopp Incidence and Characteristics of Pediatric Eosinophilic Esophagitis: A Midwestern State Analysis Children Eosinophilic esophagitis EoE pediatrics eosinophilic gastrointestinal diseases EGID |
| title | Incidence and Characteristics of Pediatric Eosinophilic Esophagitis: A Midwestern State Analysis |
| title_full | Incidence and Characteristics of Pediatric Eosinophilic Esophagitis: A Midwestern State Analysis |
| title_fullStr | Incidence and Characteristics of Pediatric Eosinophilic Esophagitis: A Midwestern State Analysis |
| title_full_unstemmed | Incidence and Characteristics of Pediatric Eosinophilic Esophagitis: A Midwestern State Analysis |
| title_short | Incidence and Characteristics of Pediatric Eosinophilic Esophagitis: A Midwestern State Analysis |
| title_sort | incidence and characteristics of pediatric eosinophilic esophagitis a midwestern state analysis |
| topic | Eosinophilic esophagitis EoE pediatrics eosinophilic gastrointestinal diseases EGID |
| url | https://www.mdpi.com/2227-9067/12/2/248 |
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