The value of habitat analysis based on 18F-PSMA-1007 PET/CT images for prostate cancer risk grading
Abstract Purpose To evaluate the performance of habitat analysis by positron emission tomography (PET)/computed tomography (CT) with 18F-prostate-specific membrane antigen (PSMA)-1007 (18F-PSMA-1007 PET/CT) for prediction of risk grading based on the Gleason Score (GS) for primary prostate cancer (P...
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BMC
2025-07-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-025-01829-4 |
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| author | Yang Wang Hongyue Zhao Zhehao Lyu Linhan Zhang Wei Han Zeyu Wang Jiafu Wang Xinyue Zhang Shibo Guo Peng Fu Changjiu Zhao |
| author_facet | Yang Wang Hongyue Zhao Zhehao Lyu Linhan Zhang Wei Han Zeyu Wang Jiafu Wang Xinyue Zhang Shibo Guo Peng Fu Changjiu Zhao |
| author_sort | Yang Wang |
| collection | DOAJ |
| description | Abstract Purpose To evaluate the performance of habitat analysis by positron emission tomography (PET)/computed tomography (CT) with 18F-prostate-specific membrane antigen (PSMA)-1007 (18F-PSMA-1007 PET/CT) for prediction of risk grading based on the Gleason Score (GS) for primary prostate cancer (PCa). Methods The data of 42 PCa patients who underwent 18F-PSMA-1007 PET/CT before puncture biopsy or radical prostatectomy were included for analysis. The whole prostate was manually contoured on PET and CT images as the volume of interest (VOI). Using the Otsu algorithm, the VOI was divided into four habitat subregions. Independent risk factors were screened and a combined model was constructed to predict GS grade by univariate logistic regression followed by multivariate logistic regression of habitat (1–4) and clinical factors (SUVmax, tPSA, fPSA/tPSA, age). Receiver operating characteristic (ROC) curves were drawn and the area under the ROC curve (AUC), sensitivity, and specificity were calculated to evaluate indicator performance. The Kappa consistency test was used to evaluate the agreement between predictive indicators and the model with pathological results. DeLong’s test was used to compare the AUC values. Results SUVmax (OR, 1.139; 95% CI, 1.034–1.253; p = 0.008) and the Habitat 2 spatial proportion (OR, 1.166; 95% CI, 1.041–1.307; p = 0.008) were identified by logistic regression analysis as independent risk factors to distinguish the GS grading of PCa, which the Habitat 2 spatial proportion represented the percentage of voxels in the region with PET-high uptake and CT-low density to the VOI. The AUC values of SUVmax, Habitat 2 spatial proportion, and the combined prediction model were 0.750 (95% CI, 0.597–0.903), 0.716 (95% CI, 0.559–0.873), and 0.823 (95% CI, 0.694–0.951), respectively. The sensitivity of Habitat 2 spatial proportion was 90.91%, which was higher than SUVmax (72.73%) and the combined model (68.18%). The specificity of the model combining SUVmax and Habitat 2 spatial proportion for risk classification of PCa was 90.00%, which was higher than either SUVmax (75.00%) or Habitat 2 spatial proportion (45.00%). Conclusion The results of this pilot study showed that the combined prediction model, as a non-invasive method, may provide additional value for risk stratification of PCa, offering new perspectives for individualized clinical diagnosis and treatment. Trial registration https://www.chictr.org.cn/ . Trial registration Registration number: ChiCTR2100052238 (retrospectively registered). |
| format | Article |
| id | doaj-art-7e02a5cf38e34bbcbdcbda5be356b351 |
| institution | DOAJ |
| issn | 1471-2342 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Medical Imaging |
| spelling | doaj-art-7e02a5cf38e34bbcbdcbda5be356b3512025-08-20T03:06:29ZengBMCBMC Medical Imaging1471-23422025-07-0125111110.1186/s12880-025-01829-4The value of habitat analysis based on 18F-PSMA-1007 PET/CT images for prostate cancer risk gradingYang Wang0Hongyue Zhao1Zhehao Lyu2Linhan Zhang3Wei Han4Zeyu Wang5Jiafu Wang6Xinyue Zhang7Shibo Guo8Peng Fu9Changjiu Zhao10Department of Nuclear Medicine, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Nuclear Medicine, The First Affiliated Hospital of Harbin Medical UniversityAbstract Purpose To evaluate the performance of habitat analysis by positron emission tomography (PET)/computed tomography (CT) with 18F-prostate-specific membrane antigen (PSMA)-1007 (18F-PSMA-1007 PET/CT) for prediction of risk grading based on the Gleason Score (GS) for primary prostate cancer (PCa). Methods The data of 42 PCa patients who underwent 18F-PSMA-1007 PET/CT before puncture biopsy or radical prostatectomy were included for analysis. The whole prostate was manually contoured on PET and CT images as the volume of interest (VOI). Using the Otsu algorithm, the VOI was divided into four habitat subregions. Independent risk factors were screened and a combined model was constructed to predict GS grade by univariate logistic regression followed by multivariate logistic regression of habitat (1–4) and clinical factors (SUVmax, tPSA, fPSA/tPSA, age). Receiver operating characteristic (ROC) curves were drawn and the area under the ROC curve (AUC), sensitivity, and specificity were calculated to evaluate indicator performance. The Kappa consistency test was used to evaluate the agreement between predictive indicators and the model with pathological results. DeLong’s test was used to compare the AUC values. Results SUVmax (OR, 1.139; 95% CI, 1.034–1.253; p = 0.008) and the Habitat 2 spatial proportion (OR, 1.166; 95% CI, 1.041–1.307; p = 0.008) were identified by logistic regression analysis as independent risk factors to distinguish the GS grading of PCa, which the Habitat 2 spatial proportion represented the percentage of voxels in the region with PET-high uptake and CT-low density to the VOI. The AUC values of SUVmax, Habitat 2 spatial proportion, and the combined prediction model were 0.750 (95% CI, 0.597–0.903), 0.716 (95% CI, 0.559–0.873), and 0.823 (95% CI, 0.694–0.951), respectively. The sensitivity of Habitat 2 spatial proportion was 90.91%, which was higher than SUVmax (72.73%) and the combined model (68.18%). The specificity of the model combining SUVmax and Habitat 2 spatial proportion for risk classification of PCa was 90.00%, which was higher than either SUVmax (75.00%) or Habitat 2 spatial proportion (45.00%). Conclusion The results of this pilot study showed that the combined prediction model, as a non-invasive method, may provide additional value for risk stratification of PCa, offering new perspectives for individualized clinical diagnosis and treatment. Trial registration https://www.chictr.org.cn/ . Trial registration Registration number: ChiCTR2100052238 (retrospectively registered).https://doi.org/10.1186/s12880-025-01829-4Habitat analysisProstate-specific membrane antigenPositron emission tomography-computed tomographyGleason scoreProstate cancer |
| spellingShingle | Yang Wang Hongyue Zhao Zhehao Lyu Linhan Zhang Wei Han Zeyu Wang Jiafu Wang Xinyue Zhang Shibo Guo Peng Fu Changjiu Zhao The value of habitat analysis based on 18F-PSMA-1007 PET/CT images for prostate cancer risk grading BMC Medical Imaging Habitat analysis Prostate-specific membrane antigen Positron emission tomography-computed tomography Gleason score Prostate cancer |
| title | The value of habitat analysis based on 18F-PSMA-1007 PET/CT images for prostate cancer risk grading |
| title_full | The value of habitat analysis based on 18F-PSMA-1007 PET/CT images for prostate cancer risk grading |
| title_fullStr | The value of habitat analysis based on 18F-PSMA-1007 PET/CT images for prostate cancer risk grading |
| title_full_unstemmed | The value of habitat analysis based on 18F-PSMA-1007 PET/CT images for prostate cancer risk grading |
| title_short | The value of habitat analysis based on 18F-PSMA-1007 PET/CT images for prostate cancer risk grading |
| title_sort | value of habitat analysis based on 18f psma 1007 pet ct images for prostate cancer risk grading |
| topic | Habitat analysis Prostate-specific membrane antigen Positron emission tomography-computed tomography Gleason score Prostate cancer |
| url | https://doi.org/10.1186/s12880-025-01829-4 |
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